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- W2364160078 abstract "Objective To study the variations of tumor necrosis factor-α(TNF-α)and high sensitivity C-reactive protein(HCRP)after acute myocardial infarction(AMI)at different times,and to investigate the effect of valsartan on the levels of TNF-αand HCRP and the occurrence of ventricular ar- rhythmia.Method 150 patients with extensive anterior wall infarction were classified randomly into two groups:MI group,valsartan group,at the same time 30 patients with coronary heart diseases excluding MI were enrolled continuously in control group.Serum TNF-αand HCRP levels were measured respectively on 1st,14th and 30th day.After 30 days,electrocardiogram monitoring was used in the three groups.Results On the 1st day,the levels of TNF-αand leucocyte in the MI and valsartan groups were higher than those in the control group(P<0.01,P<0.05),but there were no differences between two groups;on the 14th day,the level of TNF-αwas significantly different between the MI group and valsartan group(P<0.05). On the 30th day,the TNF-αlevel in the MI group was higher than that in the valsartan group(P<0.05), but no significant difference was observed between the control group and valsartan group(P>O.05).How- ever,HCRP was different among the three groups only on the first day(P<0.01).After 30 days,ventricu- lar arrhythmia occurrence in the valsartan group was significantly lower in comparison with that in the MI group(P<0.05).Via the linear correlation analysis in the MI group and valsartan group,positive rela- tionship was fount between TNF-αlevel and ventricular arrhythmia occurrence(P<0.01,P<0.05) Conclusion Serum TNF-αlevel has influence on ventricular arrhythrmia after MI.It indicates that val- sartan may decrease the occurrence of ventricular arrhythmia by reducing TNF-αin the serum." @default.
- W2364160078 created "2016-06-24" @default.
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- W2364160078 date "2007-01-01" @default.
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- W2364160078 title "Effect of valsartan on TNF-α,HCRP in the patients with ventricular arrhythmia after myocardial infarction" @default.
- W2364160078 hasPublicationYear "2007" @default.
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