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- W2364160900 abstract "Objective To investigate the influence of naringin(NG) on the proliferation and cell cycle in lymph-node cells in response to ConA. Methods Mesenteric lymph-node cells were separated from mouse sterilely,and 50,100 and 200 μmol/L of naringin stimulated lymph-node cells in response to ConA and not,and MTT tested the effect of NG on the rate of proliferation and survival;NG stimulated lymph-node cells in response to ConA at the same concentrations,and flow cytometry and western-blot were used to measure the distribution of cell cycle and the expression of P21 WAF1 in lymph-node cells. Results 50,100 and 200 μmol/L of NG didn't affect the proliferation of lymph-node cells,and didn't have cytotoxicity to lymph-node cells,but inhibited the proliferation of lymph-node cells in response to ConA obviously(P 0.01),the inhibition rates were 24.5%,49.1% and 72.4% accordingly,and arrested cell cycle at G0/G1,and inducted the expression of P21 WAF1 in a dose-dependent manner. Conclusions NG can inhibit the proliferation of lymph-node cells,and arrest their cell cycle at G0/G1 in response to ConA,which may be through inducing the expression of P21 WAF1." @default.
- W2364160900 created "2016-06-24" @default.
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- W2364160900 date "2010-01-01" @default.
- W2364160900 modified "2023-09-26" @default.
- W2364160900 title "Influence of Naringin on the Proliferation and Cell Cycle in Lymph-Node Cells in Response to ConA" @default.
- W2364160900 hasPublicationYear "2010" @default.
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