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- W2364163917 abstract "Objective To investigate the therapeutic effects of human osteoblast-stimulating factor( OSF-1) on the osteoporosis of ovariectomized rats. Methods A total of 12 female rats aged 4 months were randomly divided into 4groups: SHAM group,OVX group,human parathyroid hormone group( PTH group) and OSF-1 group. A small piece of adipose tissue was cut off from rats in SHAM group; bilateral ovariectomy was conducted in rats in the other groups.All rats were intervened per day separately since 10 weeks after the ovariectomy: SHAM and OVX groups received subcutaneous injection of 0. 2 m L / d sodium chloride solution, PTH group was given subcutaneous injection of20 μg /( kg·d) PTH,and OSF-1 group was injected subcutaneously with 80 μg /( kg · d) OSF-1. Pharmacological agents were administrated consecutively for 11 weeks,then all rats were sacrificed. Uterus was removed and weighed.Femur was removed and cleaned of adhering muscles and connective tissues. M icrocomputed tomography( micro-CT)w as used to scan proximal femur metaphysis. Results Uterus weight and bone mass in OVX group were significantly lower than those in SHAM group( P 0. 01),and the microstructure of bone trabecula was destructed in OVX group.Compared with OVX group,bone morphometric parameters in PTH and OSF-1 groups show ed significant increase on bone mineral density( BM D),BV / TV,Tb. N( P 0. 01),while Tb. Sp and TBPf were lower( P 0. 01,P 0. 05),and bone trabecula were more conspicuous in PTH and OSF-1 groups. The parameters of BM D,BV / TV and Tb. N in PTH group were higher than those in OSF-1 group( P 0. 01),and TBPf was lower than that in OSF-1 group( P 0. 01). Conclusion Subcutaneous injection of 80 μg /( kg ·d) OSF-1 can increase bone mass and improve bone microstructure in ovariectomized rats." @default.
- W2364163917 created "2016-06-24" @default.
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- W2364163917 date "2015-01-01" @default.
- W2364163917 modified "2023-09-26" @default.
- W2364163917 title "Therapeutic effects of human osteoblast-stimulating factor on osteoporosis of ovariectomized rats" @default.
- W2364163917 hasPublicationYear "2015" @default.
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