Matches in SemOpenAlex for { <https://semopenalex.org/work/W2364172859> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2364172859 abstract "Huperzine A (Hup-A,i.e.fordine)is a new alkaloid isolated from Huperziaceae plant Phlegmariurus fordii or Huperzia serrata.It is a reversible ChE inhibitor exhibiting selective inhibition on AChE.In this paper we experimented with Hup-A on sciatic-gastrocnemius and median nerve-pronator teres preparations in anesthetized rabbits.The results indicated that Hup-A caused more obvious changes in stimulation-evoked cortracticas of gattrocne-mius than those in action potentials of the muscle.By calculating from the cumulative dose-response carves,it was obtained that cumulative iv Hup-A 76.5μg/kg produced 50% increase of amplitude of twitch,but meanwhile it decreased the amplitude of tetanus induced by repetitive stimulation of 50 and 100/s by 20% and the D5 value of twitch by-30.3%.The action potentials ofboth gastrocnemius and pronator teres showed repetitive firing at stimulation with single pulse and were partially blocked during repetitive stimulation of 50 and 100/s.While EAMG rabbits were treated with iv Hup-A 25μg/ kg,the contractile function and action potentials of their morbid muscles were potentiated and improved obviously.This dose of the drug also effectively antagonized the reurcmuscular blocking action caused by tubocurarine in EAMG rabbits.In addtion it should be emphasized that one of the most important indexes of efficacy to treat a MG or EAMG with this type of drug is potenti-ation of tetanus rather than twitch." @default.
- W2364172859 created "2016-06-24" @default.
- W2364172859 creator A5015793162 @default.
- W2364172859 date "1989-01-01" @default.
- W2364172859 modified "2023-09-28" @default.
- W2364172859 title "Effect of huperzine A on the function of skeletal muscle and it's efficacy in treating experimental autoimmune myasthemia gravis (EAMG) in rabbits" @default.
- W2364172859 hasPublicationYear "1989" @default.
- W2364172859 type Work @default.
- W2364172859 sameAs 2364172859 @default.
- W2364172859 citedByCount "0" @default.
- W2364172859 crossrefType "journal-article" @default.
- W2364172859 hasAuthorship W2364172859A5015793162 @default.
- W2364172859 hasConcept C126322002 @default.
- W2364172859 hasConcept C151626666 @default.
- W2364172859 hasConcept C181199279 @default.
- W2364172859 hasConcept C185263204 @default.
- W2364172859 hasConcept C185592680 @default.
- W2364172859 hasConcept C203014093 @default.
- W2364172859 hasConcept C22070199 @default.
- W2364172859 hasConcept C24998067 @default.
- W2364172859 hasConcept C2775872116 @default.
- W2364172859 hasConcept C2776409846 @default.
- W2364172859 hasConcept C2777667214 @default.
- W2364172859 hasConcept C2778105408 @default.
- W2364172859 hasConcept C2778816929 @default.
- W2364172859 hasConcept C2779059548 @default.
- W2364172859 hasConcept C2779841045 @default.
- W2364172859 hasConcept C2779959927 @default.
- W2364172859 hasConcept C2781149210 @default.
- W2364172859 hasConcept C3020341438 @default.
- W2364172859 hasConcept C42219234 @default.
- W2364172859 hasConcept C55493867 @default.
- W2364172859 hasConcept C71240020 @default.
- W2364172859 hasConcept C71924100 @default.
- W2364172859 hasConcept C98274493 @default.
- W2364172859 hasConceptScore W2364172859C126322002 @default.
- W2364172859 hasConceptScore W2364172859C151626666 @default.
- W2364172859 hasConceptScore W2364172859C181199279 @default.
- W2364172859 hasConceptScore W2364172859C185263204 @default.
- W2364172859 hasConceptScore W2364172859C185592680 @default.
- W2364172859 hasConceptScore W2364172859C203014093 @default.
- W2364172859 hasConceptScore W2364172859C22070199 @default.
- W2364172859 hasConceptScore W2364172859C24998067 @default.
- W2364172859 hasConceptScore W2364172859C2775872116 @default.
- W2364172859 hasConceptScore W2364172859C2776409846 @default.
- W2364172859 hasConceptScore W2364172859C2777667214 @default.
- W2364172859 hasConceptScore W2364172859C2778105408 @default.
- W2364172859 hasConceptScore W2364172859C2778816929 @default.
- W2364172859 hasConceptScore W2364172859C2779059548 @default.
- W2364172859 hasConceptScore W2364172859C2779841045 @default.
- W2364172859 hasConceptScore W2364172859C2779959927 @default.
- W2364172859 hasConceptScore W2364172859C2781149210 @default.
- W2364172859 hasConceptScore W2364172859C3020341438 @default.
- W2364172859 hasConceptScore W2364172859C42219234 @default.
- W2364172859 hasConceptScore W2364172859C55493867 @default.
- W2364172859 hasConceptScore W2364172859C71240020 @default.
- W2364172859 hasConceptScore W2364172859C71924100 @default.
- W2364172859 hasConceptScore W2364172859C98274493 @default.
- W2364172859 hasLocation W23641728591 @default.
- W2364172859 hasOpenAccess W2364172859 @default.
- W2364172859 hasPrimaryLocation W23641728591 @default.
- W2364172859 hasRelatedWork W1602313315 @default.
- W2364172859 hasRelatedWork W1966807412 @default.
- W2364172859 hasRelatedWork W1973923585 @default.
- W2364172859 hasRelatedWork W1976288923 @default.
- W2364172859 hasRelatedWork W1996562054 @default.
- W2364172859 hasRelatedWork W1998613944 @default.
- W2364172859 hasRelatedWork W2000645202 @default.
- W2364172859 hasRelatedWork W2008989180 @default.
- W2364172859 hasRelatedWork W2010993179 @default.
- W2364172859 hasRelatedWork W2028121056 @default.
- W2364172859 hasRelatedWork W2061682173 @default.
- W2364172859 hasRelatedWork W2063400700 @default.
- W2364172859 hasRelatedWork W2065255600 @default.
- W2364172859 hasRelatedWork W2067576275 @default.
- W2364172859 hasRelatedWork W2088267578 @default.
- W2364172859 hasRelatedWork W2110766951 @default.
- W2364172859 hasRelatedWork W2134807644 @default.
- W2364172859 hasRelatedWork W2138554514 @default.
- W2364172859 hasRelatedWork W2143855045 @default.
- W2364172859 hasRelatedWork W2395548126 @default.
- W2364172859 isParatext "false" @default.
- W2364172859 isRetracted "false" @default.
- W2364172859 magId "2364172859" @default.
- W2364172859 workType "article" @default.