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- W2364178352 abstract "Objective:To investigate the functional importance of EGR-1gene in regulating liver regen-eration.Methods:EGR-1mRNA levels were quantified in quiescent and regenerating liver derived from replicate wildtype mice at serial time-points after partial hepatectomy or sham surgery by using real time RT-PCR.EGR-1protein in whole cell lysate derived from wildtype and EGR-1null mouse liver at48and72hours after partial hepatectomy were compared and menitored by Western blot.Results:The data showed that during liver regeneration induction of EGR-1gene expression occur6~12hours after partial hepatectomy,then declines,and increases again at48hours after partial hepatectomy,and that EGR-1protein expression was detectable12~48hours after surgery.Thus the EGR-1protein was present in regenerating liver at the time corresponding to hepatocellular mitotic progression.Conclusions:EGR-1is indeed necessary for normal liver regeneration to proceed efficiently.The functional role of EGR-1during liver regeneration involves mod-ulation of mitotic cell cycle progression." @default.
- W2364178352 created "2016-06-24" @default.
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- W2364178352 date "2004-01-01" @default.
- W2364178352 modified "2023-09-26" @default.
- W2364178352 title "Functional importance of EGR-1 in regulating liver regeneration" @default.
- W2364178352 hasPublicationYear "2004" @default.
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