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- W2364178940 abstract "Objective:To study the reaction mechanism of hydroxylethyl starch(HES) on treating acute lung injury(ALI) after cardiopulmonary bypass(CPB).Methods:40 ALI patients after cardiac operation under CPB were randomly divided into the treatment group(20 cases) and the control group(20 cases).The treatment group received continuously transfusion of hydroxylethyl starch(6% voluven) and the control group was transfused with compound sodium chloride.The central venous pressure(CVP) was maintained within 8-12mmHg in 6 h and PiCCO catheter was placed.Extravascular lung water(EVLW),cardiac output index(CI),global end-diastolic volume(GEDV) and stroke volume variation(SVV) were detected by single indicator thermodilution technique,PaO2/FiO2 was measured in 0,3,6 h.Results:EVLW of the control group and the HES group at 0 h were(9.0±2.0)mL/kg and(8.5±1.8)mL/kg,without significant difference between them(P0.05).EVLW at 6 h was lower than that at 0 h in the control group(P0.05),and EVLW at 3h,6h were lower than that at 0 h in the HES group(P0.05).EVLW at 6h in the HES group(6.1±1.4)mL/kg was lower than that in control group(7.3±1.5) mL/kg.PaO2/FiO2 of the control group and the HES group at 0h were(217±46) mmHg and(221±37) mmHg respectively,showing no significant different between the two groups(P0.05).PaO2/FiO2 at 3,6 h were lower than that at 0 h in two groups(P0.05),which at 6h in the HES group was higher than that in the control group(P0.05).GEDV at 6h was higher than 0h in the control group(P0.05).GEDV at 3 h,6 h were higher than that at 0 h in the HES group(P0.05).GEDV at 3h and 6h in the HES group were higher than those at 3 h and 6 h in the control group(P0.05).SVV at 6 h was lower than that at 0 h and 3 h in the control group(P0.05),and in the HES group SVV at 3 h and 6 h were lower than that at 0 h(P0.05),SVV at 6 h was lower than that at 3 h(P0.05).SVV at 3 h in the HES group was lower than that at 3 h in the control group(P0.05).Conclusion:Hydroxyethyl starch could reduce EVLW and improve oxygenation and symptoms in ALI after CPB." @default.
- W2364178940 created "2016-06-24" @default.
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- W2364178940 date "2011-01-01" @default.
- W2364178940 modified "2023-09-28" @default.
- W2364178940 title "Effect of hydroxylethyl starch on extravascular lung water in acute lung injury after cardiopulmonary bypass" @default.
- W2364178940 hasPublicationYear "2011" @default.
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