Matches in SemOpenAlex for { <https://semopenalex.org/work/W2364183003> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W2364183003 abstract "To establish an apoptosis model induced by 1 methyl 4 phenylpyridinium ion (MPP +) in Cerebellar granule neurons (CGNs) and assessed the effect of campneoside Ⅱ which is a compound contained in Cistanche tubulosa (Schenk) R. Wight. Methods: CGNs were treated with MPP + and then staining with methyl green and pyronin, internucleosomal DNA degradation with agarose gel electrophoresis analysis and flow cytometry of neuronal apoptosis were performed . Results: Treatment of 50 μmol·L -1 MPP + for 24 h or longer induced an initiated apoptosis in CGNs and the latter showed typical morphological features, including condensed chromatin, nuclear fragmentation and apoptotic body. Agarose gel electrophoresis of DNA from the cells treated with MPP + revealed “ladder” pattern and a time dependent increase of apoptotic peak by flowcytometric analysis. Treatment of 25 mg·L -1 campneoside Ⅱ could protect cells from apoptosis induced by MPP +. The degraded fragments of DNA decreased obviously. The viability percentage of cells was improved within 24 h. Conclusion: A new and simple method of quantitating MPP + induced apoptosis in CGNs was established. The campneoside Ⅱ inhibited MPP + induced apoptosis and the DNA fragmentation. This method can be used for studying apoptosis mechanism involved in the pathogenesis of Parkinson disease and screening anti Parkinson's disease drugs." @default.
- W2364183003 created "2016-06-24" @default.
- W2364183003 creator A5060701983 @default.
- W2364183003 date "2001-01-01" @default.
- W2364183003 modified "2023-09-25" @default.
- W2364183003 title "Campneoside II of Cistanche tubulosa (Schenk) R. Wight protects neurons from apoptosis induced by neurotoxin 1 methyl 4 phenylpyridinium (MPP" @default.
- W2364183003 hasPublicationYear "2001" @default.
- W2364183003 type Work @default.
- W2364183003 sameAs 2364183003 @default.
- W2364183003 citedByCount "0" @default.
- W2364183003 crossrefType "journal-article" @default.
- W2364183003 hasAuthorship W2364183003A5060701983 @default.
- W2364183003 hasConcept C153911025 @default.
- W2364183003 hasConcept C185592680 @default.
- W2364183003 hasConcept C18903297 @default.
- W2364183003 hasConcept C190283241 @default.
- W2364183003 hasConcept C191015642 @default.
- W2364183003 hasConcept C2778271344 @default.
- W2364183003 hasConcept C2780358027 @default.
- W2364183003 hasConcept C31573885 @default.
- W2364183003 hasConcept C43759708 @default.
- W2364183003 hasConcept C552990157 @default.
- W2364183003 hasConcept C55493867 @default.
- W2364183003 hasConcept C86803240 @default.
- W2364183003 hasConceptScore W2364183003C153911025 @default.
- W2364183003 hasConceptScore W2364183003C185592680 @default.
- W2364183003 hasConceptScore W2364183003C18903297 @default.
- W2364183003 hasConceptScore W2364183003C190283241 @default.
- W2364183003 hasConceptScore W2364183003C191015642 @default.
- W2364183003 hasConceptScore W2364183003C2778271344 @default.
- W2364183003 hasConceptScore W2364183003C2780358027 @default.
- W2364183003 hasConceptScore W2364183003C31573885 @default.
- W2364183003 hasConceptScore W2364183003C43759708 @default.
- W2364183003 hasConceptScore W2364183003C552990157 @default.
- W2364183003 hasConceptScore W2364183003C55493867 @default.
- W2364183003 hasConceptScore W2364183003C86803240 @default.
- W2364183003 hasLocation W23641830031 @default.
- W2364183003 hasOpenAccess W2364183003 @default.
- W2364183003 hasPrimaryLocation W23641830031 @default.
- W2364183003 hasRelatedWork W1037500466 @default.
- W2364183003 hasRelatedWork W1984960879 @default.
- W2364183003 hasRelatedWork W1990656391 @default.
- W2364183003 hasRelatedWork W2060703425 @default.
- W2364183003 hasRelatedWork W2082631477 @default.
- W2364183003 hasRelatedWork W2088923308 @default.
- W2364183003 hasRelatedWork W2110231800 @default.
- W2364183003 hasRelatedWork W2172079964 @default.
- W2364183003 hasRelatedWork W2357750494 @default.
- W2364183003 hasRelatedWork W2362921448 @default.
- W2364183003 hasRelatedWork W2368561461 @default.
- W2364183003 hasRelatedWork W2370936537 @default.
- W2364183003 hasRelatedWork W2378421762 @default.
- W2364183003 hasRelatedWork W2383627626 @default.
- W2364183003 hasRelatedWork W2388314472 @default.
- W2364183003 hasRelatedWork W2393724222 @default.
- W2364183003 hasRelatedWork W2409493872 @default.
- W2364183003 hasRelatedWork W2442082896 @default.
- W2364183003 hasRelatedWork W3144059106 @default.
- W2364183003 hasRelatedWork W2156146902 @default.
- W2364183003 isParatext "false" @default.
- W2364183003 isRetracted "false" @default.
- W2364183003 magId "2364183003" @default.
- W2364183003 workType "article" @default.