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- W2364186127 abstract "[Objective] To investigate the effect of berberine on heart weight/body weight ratio, myocardial morphology and peroxisome proliferator-activated receptor (PPAR) α/γ/δ protein expression in diabetic rats. [Methods] Type 2 diabetes mellitus rats were induced by a injection of 35 mg/kg streptozotocin (STZ) and a high-carbohydrate/high-fat diet for 16 weeks. From week 17 to 32, low, middle, high-dose of berberine (75, 150, 300 mg/kg), fenofibrate (100 mg/kg) and rosiglitazone (4 mg/kg) were given to diabetic rats, respectively. The myocardium structure was observed with hematoxylin-eosin (HE) staining and PPARα/γ/δ protein expression was detected by immunohistochemistry. [Results] Middle-dose, high-dose of berberine decreased the diabetic heart weight/body weight ratio (P0.01) and improved myocardial hypertrophy and interstitial fibrosis of diabetic rats. PPARγ protein was seldom detected in myocardium; middle-dose, high-dose berberine and fenofibrate strikingly restored the decreased PPARα and PPARδ expression in diabetic mycardium to near control level (P0.01). [Conclusion] Berberine modulates PPARα/δ protein expression in diabetic myocardium which may contribute to decrease heart weight/body weight ratio and ameliorate myocardium damage." @default.
- W2364186127 created "2016-06-24" @default.
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- W2364186127 date "2008-01-01" @default.
- W2364186127 modified "2023-09-23" @default.
- W2364186127 title "Effect of berberine on PPARs expression in myocardium of diabetic rats" @default.
- W2364186127 hasPublicationYear "2008" @default.
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