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• W2364189890 abstract "A B S T R A C T The purpose of the present study was to investigate the regulation of insulin biosynthesis during the perinatal period. The incorporation of [3H]leucine into total immunoreactive insulin (IRI) and into IRI fractions was measured by a specific immunoprecipitation procedure after incubation, extraction, and gel filtration in isolated 3-day-old rat pancreases without prior isolation of islets. IRI fractions were identified by their elution profile, their immunological properties, and their ability to compete with the binding of I-insulin in rat liver plasma membranes. No specific incorporation of [3H]leucine was found in the IRI eluted in the void volume, making it unlikely that this fraction behaves as a precursor of (pro)insulin in this system. In all conditions tested, the incorporation of [8H]leucine was linearly correlated with time. Optimal concentration of glucose (11 mM) activated six- to sevenfold the [8H]leucine incorporation into IRI. Theophylline or N602-dibutyryl- (db)cAMP at 1.6 mM glucose significantly increased the [8H]leucine incorporation. Glucose at 16.7 mM further enhanced the effect of both drugs. Contrarily, somatostatin (1-10 ig/ml) inhibits the rate of [8H]leucine incorporation into IRI in the presence of 11 mM glucose; this effect was observed at 5.5 mM glu" @default.
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• W2364189890 date "1976-01-01" @default.
• W2364189890 modified "2023-09-26" @default.
• W2364189890 title "in Newborn Rat Pancreas INTERACTION OF GLUCOSE, CYCLIC AMP, SOMATOSTATIN, AND SULFONYLUREAS ON THE (3H)LEUCINE INCORPORATION INTO IMMUNOREACTIVE INSULIN" @default.
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