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- W2364194211 abstract "OBJECTIVE: To investigate the vasodilative acts of water extract from Crategi Fructus on isolated porcine coronary artery rings. METHODS: The effect of water extract from Crategi Fructus 0.1, 0.3 and 0.5 mg·mL-1 on the tensions of the isolated porcine coronary artery ring induced by potassium chloride (KCl,30 mmol·L-1) was observed. Coronary artery rings were treated with Na+/Ca2+ exchanger blocker KB-R7943(1×10-6 mol·L-1), KV channel blocker 4-AP(1×10-3 mol·L-1), K+-ATP channel blocker Gli (1×10-5 mol·L-1), K+/Ca2+ channel blocker TEA (1×10-2 mol·L-1) and KiR channel blocker BaCl2(1×10-3 mol·L-1) in advance. The influence of them on vasodilative acts of water extract from Crategi Fructus was observed. RESULTS: Water extract from Crategi Fructus caused vasorelaxation of porcine coronary artery rings precontracted with KCl (30 mmol·L-1) in a concentration-dependent manner. There was no significant difference in vasorelaxation response of coronary artery rings pretreated with KB-R7943, 4-AP and Gli and those without pretreatment to water extract from Crategi Fructus(P0.05). There was significant difference in vasorelaxation response of coronary artery rings pretreated with TEA and BaCl2 and those without pretreatment to water extract from Crategi Fructus(P0.05). CONCLUSION: Water extract from Crategi Fructus could produce vasodilatation effect on KCl pre-contracted porcine coronary artery rings in concentration-dependant manner. The relaxation of the porcine coronary artery rings may be not associated with Na+/Ca2+ exchanger, KV channel and K+-ATP channel but K+/Ca2+ and KiR channel" @default.
- W2364194211 created "2016-06-24" @default.
- W2364194211 creator A5036083343 @default.
- W2364194211 date "2012-01-01" @default.
- W2364194211 modified "2023-09-25" @default.
- W2364194211 title "Vasodilative Acts of Water Extract from Crategi Fructus on Isolated Porcine Coronary Artery Rings" @default.
- W2364194211 hasPublicationYear "2012" @default.
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