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- W2364196679 abstract "Objective To inverstigate the change of the platelet function and plasma level of nitric oxide in patients with pulmonary thromboembolism.Methods P-selectin expressed on platelets were analyzed by flow cytometry,and plasma of NO,vWF,TXB_2,6-keto-PGF_1αwere measured by biochemisty and ELISA techniques.The change of these parameters were compared 1 week later.When treated with L-Arg,the expression of P-selectin on platelet was studied.After pretreatment with L-NAME,the effect of L-Arg on P-seletin was also studied.Results The level of P-seletin,vWF,TXB_2 in the trial group were higher than those in the control group(P0.01),but levels NO and 6-keto-PGF_1α were lower in trial group than control group(P0.01).When treated with L-Arg,the expression of P-seletin on platelet decreased(P0.01),after pretreatment with L-NAME,the effect of L-Arg on P-selectin were blunted(P0.05).Conclusion NO inhibited expression of P-selectin on the platelet and play a role in platelet activation and development of thrombus in PTE patients." @default.
- W2364196679 created "2016-06-24" @default.
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- W2364196679 date "2006-01-01" @default.
- W2364196679 modified "2023-09-28" @default.
- W2364196679 title "Change of plasma level of nitric oxide and the platelet function in the patients with pulmonary thromboembolism" @default.
- W2364196679 hasPublicationYear "2006" @default.
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