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- W2364202230 abstract "Objective To evaluate the therapeutic efficiency and adverse effect of the fludarabinecontaining regimens in the treatment of low grade non-Hodgkin＇s lymphoma. Methods Thirty-two patients with low grade non-Hodgkin＇s lymphoma consisting of 19 primary one and 13 relapsed or refractory were treated with fludarabine-containing regimens, which included FMD （fludarabine, mitoxantrone and dexamethasone）; FMC （fludarabine, cyclophosphamide and mitoxantrone）and FC （fludarabine and cyclophosphamide）. Results The average course completed in these 32 patients was 4. 1 with a complete response rate （CR）, partial response rate （PR）and overall response rate （OR）of 65.6%, 18.8% and 84.4%, respectively. There were no significant difference in CR, PR and OR between primary and relapsed or refractory group （71.4%, 21.0%, 92.4% vs. 46.2%, 13.1%, 59.3% , respectively）. Myelotoxicity and immunotoxicity was the dominating adverse effects. Ⅲ to Ⅳ grade granulocytopenia and thrombocytopenia were observed in 31.3% （10/32） and 9. 4% （3/32） of these patients respectively. Infection developed in 7 patients, and two of them died of pulmonary infection. The median follow-up period was 16 months （ 1-30 months）with 2-year overall-survival rate （OS） and progression-free survival rate （PFS） of 93.8% and 84.4%, respectively. No significant difference was observed between primary and relapsed or refractory group in OS （100% vs. 76.9%）and PFS （94.7% vs. 69.2%）. Conclusion Fludarabine- containing regimens is well tolerated and effective in the treatment of low grade non-Hodgkin＇s lymphoma.Key words: Fludarabine; Lymphoma, non-Hodgkin's" @default.
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- W2364202230 date "2007-09-01" @default.
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- W2364202230 title "[A clinical observation of fludarabine-containing regimens in the treatment of low grade non-Hodgkin's lymphoma]." @default.
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