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- W2364204490 abstract "In 2005,interleukin-33(IL-33) was reported as a newly described member of the IL-1 cytokine superfamily.In 1989,ST2 was first identified as a member of the IL-1 cytokine superfamily.After that,Baekkevold reported a nuclear factor present in endothelial cells of high endothelial venules(NF-HEV),hence initially called NF-HEV.In 2005,Schmitz et al established that NF-HEV was the ligand for ST2,and renamed NF-HEV as IL-33.Since the year 2005,our understanding of the biology of IL-33 has advanced considerably.Along with Th2 activation,IL-33 strongly induces Th2 cytokine production and can promote the pathogenesis of Th2-related disease such as bronchial asthma.This review focuses on the molecular structure,expression,biology and contribution of IL-33 to the pathophysiology of bronchial asthma." @default.
- W2364204490 created "2016-06-24" @default.
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- W2364204490 date "2012-01-01" @default.
- W2364204490 modified "2023-09-23" @default.
- W2364204490 title "Interleukin-33 and bronchial asthma" @default.
- W2364204490 hasPublicationYear "2012" @default.
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