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- W2364205655 abstract "Objective To investigate basic diseases,type and dosage of anti-platelet drugs,other drugs influencing the effects of anti-platelet treatment,results of platelet aggregation function tests and incidences of hemorrhagic accidents,so as to provide improvement and guidance for the anti-platelet therapy among senile patients.Methods 1404 senile inpatients or outpatients were selected,who took anti-platelet drugs and were assayed for platelet aggregation function regularly; and the basic diseases,type and dosage of anti-platelet drugs,other drugs influencing the effects of anti-platelet treatment,results of platelet aggregation function tests and incidence of hemorrhagic accident were all analyzed.Results Compared with the patients without any antiplatelet treatment,the patients taking aspirin or clopidogrel or both displayed a statistically significant descending of platelet aggregation function level(P0.01);compared with the patients just taking clopidogrel,the patients taking clopidogrel with statin and(or) PPI showed lower descending of platelet aggregation function level of ADP with statistically significant difference(P 0.01);compared with the patients taking only clopidogrel+aspirin,the patients taking clopidogre with statin and(or) PPI,and the patients taking clopidogrel +aspirin with statin and(or) PPI,also showed lower descending on platelet aggregation function level of ADP with statistically significant difference(P0.01).Conclusions A certain ratio of resistance to aspirin and clopidogrel still exists in senile patients.Anti-platelet effect of clopidogrel was influenced potentially by statin and PPI.More reasonable combined pharmacotherapy,high individualized anti-platelet treatment and more accurate test on platelet aggregation function should be used clinically as soon as possible." @default.
- W2364205655 created "2016-06-24" @default.
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- W2364205655 date "2012-01-01" @default.
- W2364205655 modified "2023-09-23" @default.
- W2364205655 title "Investigation of anti-platelet therapy among senile patients" @default.
- W2364205655 hasPublicationYear "2012" @default.
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