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- W2364207029 abstract "Objective: To study the difference in therapeutic effects and side effects between quetiapine and perphenazine.Methods: Sixteen comparative studies of quetiapine and perphenazine in the treatment of schizophrenia were analyzed by meta-analysis in therapeutic effects and side effects.Results: There was no significant difference on clinical obvious effective rate between quetiapine group and perphenazine group(71.30% vs 69.12%,OR=1.13,95%CI(0.88,1.46),P=0.32),no significant difference on clinical effective rate between quetiapine group and perphenazine group(76.72% vs 76.16%,OR=1.07,95%CI(0.74,1.56),P=0.71).The incidences of psychomotility(OR=1.93,95%CI(1.47,2.54),P0.00001),cardiovascular system(OR=1.78,95%CI(1.34,2.38),P0.00001) and weight gain(OR=1.76,95%CI(1.17,2.62),P=0.006) in perphenazine group were significantly lower than those in quetiapine group,but the incidences of EPS(OR=0.27,95%CI(0.19,0.38),P0.00001) and autonomic nerve system(OR=0.69,95%CI(0.53,0.88),P=0.004) in quetiapine group were significantly lower than those in perphenazine group,the hepatic dysfunction were not signifinicantly different.Conclusion: Their therapeutic effects of quetiapine and perphenazine for treating schizophrenia were similar,and the side effects of the two drugs were different." @default.
- W2364207029 created "2016-06-24" @default.
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- W2364207029 date "2010-01-01" @default.
- W2364207029 modified "2023-09-23" @default.
- W2364207029 title "Meta-analysis of Comparative Study on Quetiapine and Perphenazine in the Treatment of Schizophrenia" @default.
- W2364207029 hasPublicationYear "2010" @default.
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