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- W2364207830 abstract "Objective To study the role of hybrid bioartificial liver(HBL) on clearing proinflammatory cytokines and endotoxin from patients with acute and sub-acute liver failure and the effects of SIRS and MODS.Methods HBL consisted of plasma exchange and porcine hepatocyte-based bioartificial liver.5 cases with severe liver failure(3 acute and 2 subacute) were treated with HBL.The clinical signs and symptoms,total bilirubin(TBIL),serum ammonia,endotoxin and prothrombin activity(PTA),cholinesterase (CHE) were recorded pre,during and post treatment.Results 2 patients recovered spontaneously recovery and 1 patient bridged for OLT successfully,another 2 patients died On the 8 th day and 21 st day.The survival and effective rate were 3/5 and 4/5 respectively.3 patients with hepatic coma improved in the level of encephalopathy.All patientss PTA and CHE were increased significantly (P0 01),while the serum TBIL,endotoxin,TNF-α,IL 6 were decreased.Conclusion The proinflammatory cytokines(TNF-α,IL 6 and endotoxin)were significantly removed by HBL which appeared to be effective to block the SIRS to MODS stage in patients with acute and sub-acute liver failure. [" @default.
- W2364207830 created "2016-06-24" @default.
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- W2364207830 date "2002-01-01" @default.
- W2364207830 modified "2023-09-25" @default.
- W2364207830 title "The clinical research of hybrid bioartificial liver for blocking the SIRS to MODS stage in patients with fulminant liver failure" @default.
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