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- W2364221852 abstract "Objective:To establish the steriod-induced femoral head of necrosis(SANFH)rats model with type of deficiency of kidney-Yang.Methods:30 SD rats were randomly divided into normal group,model group and Youguiyin group.SANFH rat model was established by injecting Hydroprednison.Youguiyingroup was administered with Youguiyin orally,while normal group and model group were given the same amount of saline.All the animals were sacrificed at the end of the 6th week for obtaining femoral heads.HE staining was used for observing morphological changes,while Hormone contents(TSH,T4,ACTH,COR and T)in serum of the Hypothalamic-pituitary-target gland axises were detected by radio immunoassay.Results:Compared to normal group,both of the morphology and the function of the Hypothalamic-pituitary-target gland axises were inhibited significantly in SANFH rats:the weight of pituitary,adrenal and throid decreased(P0.01),the weight of testis decreased(P0.05).The levels of ACTH and T decreased(P0.01).The levels of TSH,T4 and COR decreased(P0.05).The ratio of cAMP/cGMP decreased(P0.01).However,the Youguiyin group can partly antagonist the inhibition of the HPA axis,alter the disordered sex hormone and thyroid hormone,reverse the necrosis of femoral head.Conclusion:The animal model which was established only by injecting Hydroprednison is consistent with Traditional Chinese Medicine(TCM)clinical situation.Since there is few intervenient factors,it may be a stable and reliable modeling method for integration of disease and syndrome in TCM." @default.
- W2364221852 created "2016-06-24" @default.
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- W2364221852 date "2013-01-01" @default.
- W2364221852 modified "2023-09-22" @default.
- W2364221852 title "Methods and Evaluation on the Steriod-induced Femoral Head of Necrosis Rats Model with Type of Deficiency of Kidney-Yang" @default.
- W2364221852 hasPublicationYear "2013" @default.
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