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- W2364222489 abstract "Objective To investigate the expression of c erb B 2 and Cathepsin D in gastric carcinoma and its correlation with the biological behavior of gastric carcinoma (GC). Methods The expression was studied by immunohistochemical technique. The expression of c erb B 2 and Cathepsin D were analyzed with their relation to histologic types, depth of invasion, growth pattern, lymph node metastasis and prognosis of gastric carcinoma. Results Thirty nine of the 102 gastric carcinoma specimens (38.24%) were positive for c erb B 2 and correlated with depth of invasion ( P 0.05) and lymph node metastasis ( P 0.05); eighty three of the 102 gastric carcinoma specimens (81.37%) were positive for Cathepsin D and correlated with depth of invasion ( P 0.05), growth pattern ( P 0.05), lymph node metastasis ( P 0.05) and blood vessels cancer embolus ( P 0.05). Prognosis of patients with gastric carcinoma with positive expression of c erb B 2 or Cathepsin D was poor. The 5 year survival rate was significantly lower in gastric carcinoma patients with positive expression of c erb B 2 or Cathepsin D. Conclusion c erb B 2 and Cathepsin D are highly related to growth, invasion, metastasis and prognosis of gastric carcinoma." @default.
- W2364222489 created "2016-06-24" @default.
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- W2364222489 date "2002-01-01" @default.
- W2364222489 modified "2023-09-25" @default.
- W2364222489 title "The Expression of c-erb B-2 and Cathepsin D in Gastric Carcinoma and Its Correlation to the Biological Behavior of Gastric Carcinoma" @default.
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