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- W2364227979 abstract "Objective Recent findings indicate that the serological and biochemical characteristics of porcine erythrocytes share many similarities with human red blood cell (hRBC). Scientists believed that humanized porcine red blood cells (pRBC) could be used as one alternative source for human blood transfusion. Methods In order to eliminate αGal antigen and non-αGal on the surface of pRBC, recombinant soybean α-Galactosidase (rSα-GalE) constructed by our lab was used to remove terminal αGal residues from αGal antigen, and mPEG-BTC was used to camouflage non-αGal xenoantigen on the surface of pRBC. Results The carbohydrate structures of αGal xenoantigen of pRBC treated with rSα-GalE were completely modified. The antigenic determinants of αGal and non-αGal xenoantigen on the surface of pRBC were successfully camouflaged through mPEG-BTC modification. But this modification needed higher concentration of mPEG-BTC which could cause slight structure damage. Considering this, with combination of αGal xenoantigen conversion by rSα-GalE and chemical camouflage of non-αGal xenoantigen with lower concentration of mPEG-BTC, the antigenic determinants of pRBC were attenuated and hemagglutination were diminished.Conclusion The morphology, structures, functions and deformability of pRBC modified with rSα-GalE, mPEG-BTC and rSα-GalE+ mPEG-BTC were normal." @default.
- W2364227979 created "2016-06-24" @default.
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- W2364227979 date "2006-01-01" @default.
- W2364227979 modified "2023-09-26" @default.
- W2364227979 title "Chemical modification of antigens on porcine red blood cells:the preliminary study on xenotransfusion" @default.
- W2364227979 hasPublicationYear "2006" @default.
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