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- W2364228020 abstract "Objective:To explore the variation of depressive symptoms before and after antipsychotic treatment and relations between depressive symptoms and outcomes among treatment-naive,first-episode schizophrenic patients in a 9-year follow-up study.Methods:Totally 164 first-episode inpatients met for Chinese Classification of Mental Disorders,Second Edition,Revised(CCMD-2-R) criteria of schizophrenia were recruited.They were assessed with the Hamilton Depression Rating Scale(HAMD),Brief Psychiatric Rating Scale(BPRS),Scale for the Assessment for Negative Symptoms Chinese Version(SANS-CV),Clinical Global Impression scale(CGI),and Global Assessment of Functioning scale(GAF) at admission and each of 9 years after admission.Results:Totally 139 cases were analyzed in ITT analysis.The rates of depressive symptoms in every year assessments for 9-year follow-up were 9.4%,13.7%,7.2%,8.6%,7.9%,6.5%,3.7%,6.5%,and 3.6%,(Cochran Q=22.18,P=0.005).The total scores of HAMD assessed at 1 to 9 years were all lower than that at admission(Ps0.001).There were slight differences among 1 to 9 years' total scores of HAMD(Ps0.01).The total scores of HAMD at admission were not significantly correlated with the remission time,1 to 9 years' total scores of SANS,GAF,CGI,and BPRS except depressive-anxiety subscale.Conclusion:It suggests that after 1-year' s antipsychotic treatment,the depressive symptoms of patients with schizophrenia could remit rapidly,and depressive symptoms fluctuate around a relatively low level.The severity of depressive symptoms at acute phase of first-episode schizophrenia could not predict long time outcomes of the disease." @default.
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- W2364228020 date "2012-01-01" @default.
- W2364228020 modified "2023-09-23" @default.
- W2364228020 title "Depressive symptoms in first-episode schizophrenia:A 9-year follow-up study" @default.
- W2364228020 hasPublicationYear "2012" @default.
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