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- W2364229519 abstract "OBJECTIVE: To study the effect on colon cancer cell proliferation and invasion inhibited by histone deacetylase inhibitor(HDACIs) MS-275.METHODS: MTT was used to test the inhibition of Caco-2 cell proliferation.Transwell experiment was carried on to test the influence of Caco-2 cell invasion.While expression of matrix metalloproteinase-7 was tested by western blotting.RESULTS: Treated by MS-275,the proliferation of Caco-2 cells was inhibited effectively.Cell vialbility inhibition rate was 54.50% with treatment by MS-275(8 μmol/L) for 48 hours,compared with control group,the difference was significant(P0.01);Treated by MS-275,cell invasion of Caco-2 cells was significantly reduced,cell invasion rate decreased to 15.70% with treatment by MS-275(8 μmol/L) for 24 hours,compared with the control group,the difference was significant(P0.01);The MS-275 could down-regulate matrix metalloproteinase-7 protein expression.Western blot showed that MMP-7 protein expression was reduced to 18.00% with treatment by MS-275(8 μmol/L) for 24 hours,and the differences of treated group and control culture were significant(P0.01).CONCLUSION: MS-275 can effectively inhibit colon cancer cell Caco-2 proliferation activity;MS-275 also can inhibit MMP-7 protein expression level effectively in Caco-2 cells;MS-275 can inhibit colon cancer cell Caco-2 invasion by inhibiting the expression of MMP-7 protein." @default.
- W2364229519 created "2016-06-24" @default.
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- W2364229519 date "2012-01-01" @default.
- W2364229519 modified "2023-09-26" @default.
- W2364229519 title "Inhibition effect of MS-275 on colon cancer cell proliferation and invasion" @default.
- W2364229519 hasPublicationYear "2012" @default.
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