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• W236423874 abstract "Background: Studies from our lab have shown that decreasing myocardial G protein-coupled receptor kinase 2 (GRK2) expression or preventing GRK2 activation with an inhibitory peptide (βARKct) can prevent or rescue heart failure after myocardial infarction. In this study we investigated the acute cardiac effects associated with lowered myocyte GRK2 expression in a mouse model of ischemia/reperfusion (I/R) injury. Methods: Cardiomyocyte-specific GRK2 knockout (KO) mice were used with either GRK2 deleted at birth or inducible GRK2 deletion along with appropriate control mice that included GRK2 floxed mice and αMHC-Cre and MerCreMer mice. All mice were subjected to sham or 30 min myocardial ischemia via coronary artery ligation followed by 24 hrs reperfusion. Cardiac function, infarct size, tissue apoptosis (TUNEL and Caspase activity) and changes in the activation state of various signaling molecules (Akt, GSK3β, ERK, p38, JNK and cytochrome C) were analyzed. Results: Echo and hemodynamic measurements showed ..." @default.
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• W236423874 date "2010-11-23" @default.
• W236423874 modified "2023-09-28" @default.
• W236423874 title "Abstract 9485: Cardiac G Protein-Coupled Receptor Kinase 2 Knockdown Decreases Ischemia/Reperfusion-Induced Injury and Improves Cardiac Function through Anti-Apoptotic Mechanisms" @default.
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