FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2364245896> ?p ?o ?g. }

• W2364245896 endingPage "32" @default.
• W2364245896 startingPage "25" @default.
• W2364245896 abstract "To explore changes of B and T lymphocyte attenuator (BTLA), superoxide dismutase (SOD), catalase (CAT), total antioxidant capacity (TAOC), reactive oxygen species (ROS), reactive nitrogen species (RNS), malondialdehyde (MDA) in ankylosing spondylitis (AS) patients, and the effect of Xinfeng Capsule (XFC) on them.Totally 120 AS patients were assigned to two groups according to random digit table method, the XFC group (3 XFC pills each time, 3 times a day) and the SASP group (4 SASP tablets each time, twice a day), 60 in each group. All patients were treated for 3 months. Another 60 healthy subjects were recruited as a healthy control group. The expression frequency and activation levels of BTLA were detected using flow cytometry. Serum oxidative stress indices (such as SOD and CAT, TAOC, ROS, RNS, MDA) and contents of cytokines [tumor necrosis factor α (TNF-α), IL-1β, IL-4, and IL-10] were detected using enzyme-linked immunoassay (ELISA). Erythrocyte sedimentation rate (ESR) was detected using Westergren method. High-sensitivity C-reactive protein (Hs-CRP) was detected using HITACHI 7060 type automatic biochemical analyzer. Clinical efficacies of ASAS 20 and BASDAI50 were assessed using VAS. Correlation analysis between scoring for quality of life and BTLA expression frequency was performed.(1) Clinical efficacies of ASAS 20 and BASDAI50 were significantly better in the XFC group than in the SASP group (P < 0.01). (2) Compared with the healthy control group, BTLA expressions in the peripheral blood of AS patients decreased significantly (P <0. 05); SOD, CAT, and TAOC values significantly decreased (P < 0.01, P < 0.05); ROS, RNS, and MDA values significantly increased (P < 0.01, P < 0.05); TNF-α, IL-1β, ESR, and Hs-CRP values significantly increased (P < 0.01); IL-4 and IL-10 values decreased significantly (P < 0.01, P < 0.05). (3) Compared with pre-treatment in the same group, BTLA/CD19 + B, BTLA/CD24 + B, SOD, TAOC, IL-4, SF-36 [physical functioning (PF), social functioning (SF), role limitation due to physical problems (RP), role limitation due to emotional problems (RE), body pain (BP), mental health (MH), vitality (VT), general health (GH)] were significantly elevated; ROS, MDA, TNF-α, ESR, Hs- CRP, VAS, BASDAI and BASFI, BAS-G were significantly lower in the peripheral blood of the two groups after treatment (P < 0.01, P < 0.05). Better effect was shown in the XFC group in elevating BTLA/CD19+ B, BTLA/CD24 + B, SOD, TAOC, IL-10, BP, MH, VT, and SF; and lowering ROS, IL-1β, MDA, TNF-α, ESR, Hs-CRP, VAS, BASDAI, BASFI, and BAS-G (P < 0.01, P < 0.05). (4) Pearson correlation analysis showed, BTLA/CD19 + B expression of the peripheral blood was positively correlated with SOD, CAT, TAOC, IL-4, IL-10, GH, RP, BP, and SF (r = 0.431, 0.325, 0.318, 0.316, 0.348, 0.314, 0.358, 0.318, 0.326, respectively, P < 0.05, P < 0.01), while it was negative correlated with ROS, MDA, TNF-α, IL-1β, ESR, VAS, and BASDAI (r = -0.342, -0.368, -0.334, -0.354, -0.324, -0.372, -0.342, respectively, P < 0.05, P < 0.01). BTLA/CD24 B expression of the peripheral blood was positively correlated with SOD, TAOC, IL-4, IL-10, GH, RP, BP, SF, RE, MH, VT (r = 0.358, 0.352, 0.372, 0.436, 0.435, 0.326, 0.352, 0.345, 0.326, 0.343, 0.332, respectively, P < 0.05, P < 0.01), while it was negative correlated with ROS, RNS, MDA, ESR, Hs-CRP, VAS, BASDAI, and BASFI (r = -0.447, -0.336, -0.405, -0. 395, -0. 358, -0.436, -0.338, -0.425, respectively, P < 0.05, P < 0.01).XFC could improve BTLA expression in the peripheral blood of AS patients, negatively regulate activation and proliferation of B cells, and reduce abnormal immune responses and oxidative stress injury, thereby effectively alleviating joint stiffness and pain." @default.
• W2364245896 created "2016-06-24" @default.
• W2364245896 creator A5025035488 @default.
• W2364245896 creator A5026453776 @default.
• W2364245896 creator A5045724924 @default.
• W2364245896 creator A5046292333 @default.
• W2364245896 creator A5083256792 @default.
• W2364245896 date "2015-01-01" @default.
• W2364245896 modified "2023-09-26" @default.
• W2364245896 title "[Exploration of the mechanism of xinfeng capsule in the treatment of ankylosing spondylitis based on B and T lymphocyte attenuator and oxidative stress]." @default.
• W2364245896 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25790670" @default.
• W2364245896 hasPublicationYear "2015" @default.
• W2364245896 type Work @default.
• W2364245896 sameAs 2364245896 @default.
• W2364245896 citedByCount "0" @default.
• W2364245896 crossrefType "journal-article" @default.
• W2364245896 hasAuthorship W2364245896A5025035488 @default.
• W2364245896 hasAuthorship W2364245896A5026453776 @default.
• W2364245896 hasAuthorship W2364245896A5045724924 @default.
• W2364245896 hasAuthorship W2364245896A5046292333 @default.
• W2364245896 hasAuthorship W2364245896A5083256792 @default.
• W2364245896 hasConcept C126322002 @default.
• W2364245896 hasConcept C134018914 @default.
• W2364245896 hasConcept C142724271 @default.
• W2364245896 hasConcept C185592680 @default.
• W2364245896 hasConcept C188947578 @default.
• W2364245896 hasConcept C203014093 @default.
• W2364245896 hasConcept C204787440 @default.
• W2364245896 hasConcept C2775838275 @default.
• W2364245896 hasConcept C2776151105 @default.
• W2364245896 hasConcept C2776260265 @default.
• W2364245896 hasConcept C2777077863 @default.
• W2364245896 hasConcept C2777402515 @default.
• W2364245896 hasConcept C2777453003 @default.
• W2364245896 hasConcept C2777761686 @default.
• W2364245896 hasConcept C2777946188 @default.
• W2364245896 hasConcept C2778143017 @default.
• W2364245896 hasConcept C2778401633 @default.
• W2364245896 hasConcept C2780237676 @default.
• W2364245896 hasConcept C2780415856 @default.
• W2364245896 hasConcept C2992881475 @default.
• W2364245896 hasConcept C48349386 @default.
• W2364245896 hasConcept C55493867 @default.
• W2364245896 hasConcept C71924100 @default.
• W2364245896 hasConcept C8891405 @default.
• W2364245896 hasConcept C90924648 @default.
• W2364245896 hasConceptScore W2364245896C126322002 @default.
• W2364245896 hasConceptScore W2364245896C134018914 @default.
• W2364245896 hasConceptScore W2364245896C142724271 @default.
• W2364245896 hasConceptScore W2364245896C185592680 @default.
• W2364245896 hasConceptScore W2364245896C188947578 @default.
• W2364245896 hasConceptScore W2364245896C203014093 @default.
• W2364245896 hasConceptScore W2364245896C204787440 @default.
• W2364245896 hasConceptScore W2364245896C2775838275 @default.
• W2364245896 hasConceptScore W2364245896C2776151105 @default.
• W2364245896 hasConceptScore W2364245896C2776260265 @default.
• W2364245896 hasConceptScore W2364245896C2777077863 @default.
• W2364245896 hasConceptScore W2364245896C2777402515 @default.
• W2364245896 hasConceptScore W2364245896C2777453003 @default.
• W2364245896 hasConceptScore W2364245896C2777761686 @default.
• W2364245896 hasConceptScore W2364245896C2777946188 @default.
• W2364245896 hasConceptScore W2364245896C2778143017 @default.
• W2364245896 hasConceptScore W2364245896C2778401633 @default.
• W2364245896 hasConceptScore W2364245896C2780237676 @default.
• W2364245896 hasConceptScore W2364245896C2780415856 @default.
• W2364245896 hasConceptScore W2364245896C2992881475 @default.
• W2364245896 hasConceptScore W2364245896C48349386 @default.
• W2364245896 hasConceptScore W2364245896C55493867 @default.
• W2364245896 hasConceptScore W2364245896C71924100 @default.
• W2364245896 hasConceptScore W2364245896C8891405 @default.
• W2364245896 hasConceptScore W2364245896C90924648 @default.
• W2364245896 hasIssue "1" @default.
• W2364245896 hasLocation W23642458961 @default.
• W2364245896 hasOpenAccess W2364245896 @default.
• W2364245896 hasPrimaryLocation W23642458961 @default.
• W2364245896 hasRelatedWork W1979765597 @default.
• W2364245896 hasRelatedWork W1996937640 @default.
• W2364245896 hasRelatedWork W2043092290 @default.
• W2364245896 hasRelatedWork W2065397180 @default.
• W2364245896 hasRelatedWork W2203012171 @default.
• W2364245896 hasRelatedWork W2254136192 @default.
• W2364245896 hasRelatedWork W2364245896 @default.
• W2364245896 hasRelatedWork W2982362007 @default.
• W2364245896 hasRelatedWork W3117035660 @default.
• W2364245896 hasRelatedWork W3142469238 @default.
• W2364245896 hasVolume "35" @default.
• W2364245896 isParatext "false" @default.
• W2364245896 isRetracted "false" @default.
• W2364245896 magId "2364245896" @default.
• W2364245896 workType "article" @default.