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- W2364250464 abstract "Objective:To observe the effect of mild hypothermia treatment on respiratory chain enzymes of mitochondrion following traumatic brain injury(TBI).Methods:Male Sprague-Dawley rats 24,randomly divided into three groups,normal control group(C,n = 8),hypothermic injury group(HI,31 ℃～33 ℃,6 h,n = 8) and normothermic injury group(NI,36 ℃～37 ℃,n = 8).The groups of HI and NI were subjected to moderate injury of left brain by lateral fluid pressure device.The ipsilateral brain samples were dissected and homogenized after 24 h TBI.Mitochondrion was extracted by density and speed-centrifugation.The activity and purity of mitochondrion were identified by Janus green B staining and electron microscopy(EM)respectively,and then activities of succinate dehydrogenase(SDH),cytochrome C oxidase(CCO) and nicotinamide ade-nine dinucleotide(NADH) were tested.Results:Compared with C group,activities of CCO and NADH significantly decreased in NI group(P0.05).Activity of SDH kept normal after 6 h TBI in HI group(P0.05).Conclusion:These findings suggested that activity of mitochondrial respiratory chain enzymes decreased after TBI,and mild hypothermia could maintain the SDH activity of the mitochondrial after TBI and lighten the secondary energy loss,and then protect the brain tissue." @default.
- W2364250464 created "2016-06-24" @default.
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- W2364250464 date "2008-01-01" @default.
- W2364250464 modified "2023-09-26" @default.
- W2364250464 title "Effect of Mild Hypothermia Treatment on Respiratory Chain Enzymes of Mitochondrion Following Traumatic Brain Injury in SD Rats" @default.
- W2364250464 hasPublicationYear "2008" @default.
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