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- W2364256706 abstract "Objective To explore the correlation of platelet activating factor acetylhydrolase(PAF-AH) and Henoch-Schonlein purpura nephritis(HSPN). Methods Seventy children with Henoch-Schonlein purpura(HSP) who were admitted into the General Hospital of Ningxia Medical University from Oct.2010 to Apr.2011 were selected,and according to whether they had the kidney damage,they were divi-ded into non-HSPN group and HSPN group.Fifty healthy children were collected as healthy control group.And real-time fluorescent quantitive polymerase chain reaction was used to detect the expression of PAF-AH mRNA.Serum PAF-AH,vascular endothelial growth factor(VEGF),and heat shock protein 70(HSP70) levels were detected by using enzyme-linked immunosorbent assay.SPSS 13.0 software was used to analyze the data. Results 1.The expressions of PAF-AH mRNA and protein,VEGF and HSP70 in HSPN group were higher than those in non-HSPN group and healthy control group,which were significantly positive(Pa0.01).The expressions of PAF-AH protein,VEGF and HSP70 in non-HSPN group were higher than those in healthy control group,which were significantly positive(Pa0.01).2.PAF-AH was positively correlated with VEGF and HSP70 in HSPN group(Pa0.01). Conclusion PAF-AH is involved in the pathogenesis of HSP,which has relevance with kidney damage." @default.
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- W2364256706 date "2012-01-01" @default.
- W2364256706 modified "2023-09-28" @default.
- W2364256706 title "Correlation of Platelet Activating Factor Acetylhydrolase and Henoch-Schonlein Purpura Nephritis" @default.
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