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- W2364258917 abstract "Objective: To investigate whether administration of interleukin (IL)-12 and IL-18 to mice can induce spleen deficiency or not and discuss the relationship between spleen deficiency and IL-12, IL-18. Methods: Sixty mice were randomly divided into spleen deficiency group, IL group and control group. Spleen deficiency model was prepared with reserpine. Mice in IL group were injected with IL-12 and IL-18 intraperitoneally each day. The level of plasma IL-12 and IL-18 of the three groups was measured with radioimmunoassay. Results: IL-12 and IL-18 induced prominent spleen deficiency syndrome similar with that induced by reserpine. The level of plasma IL-12 and IL-18 of spleen deficiency group and IL group was higher than that of the control group (P0.01).Conclusion: IL-12 and IL-18 could induce spleen deficiency and the level of plasma IL-12 and IL-18 could be regarded as the reference parameter of the spleen deficiency syndrome." @default.
- W2364258917 created "2016-06-24" @default.
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- W2364258917 date "2003-01-01" @default.
- W2364258917 modified "2023-09-27" @default.
- W2364258917 title "Study on Mice with Spleen Deficiency Induced by IL-18 and IL-12" @default.
- W2364258917 hasPublicationYear "2003" @default.
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