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- W2364263013 abstract "Background The slow reflow phenomenon(SRP) occurred in 10%-30% patients with acute myo- cardial infarction (AMI) after percutaneous coronary intervention (PCI) indicating no enough perfusion was restored. Prevention and treatment SRP will improve the mortality and morbility after AMI.Objective To study the effect of intracoronary administration in infarct related artery(IRA) by combined anisodamine and adenosine on SRP after primary PCI in patients with AMI.Methods Fifty-one patients were received intracoronary injection of anisodam- ine (500 μg anisodamine,n=26,group A) or anisodamine plus adenosine (500 μg anisodamine+adenosine 3 mg,n =25,group B) after 10 minutes after nitroglycerin (200 μg).TIMI frame count was counted at 1,3,and 10 min as index of speed and extant of repenfusion.Results No significant change of frame numbers in TIMI was found at 1,3 and 10 min after intracoronary administration of nitroglycerin (P0.05).However,TIMI frames count was decreased by 56.6%,54.4%,and 52.80% at 1 min,3 min and 10 min,respectively,with average TIMI grade im- proved from (1.75±0.46) to (2.73±0.44) (P0.05) after anisodamine.Combined treatment significantly de- creased TIMI frames count by 59.5%,58.6%,and 55.8% and increased average coronary blood flow of TIMI grade from (1.72±0.52) to (2.82±0.36) (P0.05) with no changes in blood pressure(P0.05).The heart rate was increased significantly in goup A but not in group B.Conclusion Intracoronary administration of combined aniso- damine with adenosine is safe and effective to prevent SRP after primary PCI in patients with AMI." @default.
- W2364263013 created "2016-06-24" @default.
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- W2364263013 date "2008-01-01" @default.
- W2364263013 modified "2023-09-24" @default.
- W2364263013 title "lntracoronary Administration of Combined Anisodamine with Adenosine Improves Slow Reflow Phenomenon After Pri- mary Percutaneous Coronarv Intervention in Patients with Acute Mvocardial Infarction" @default.
- W2364263013 hasPublicationYear "2008" @default.
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