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- W2364264294 abstract "Objective:To observe the effects of naloxone on cardiac perfor ma nce during the cardiopulmonary resuscitation in piglets with cardiac arrest indu ced by hypoxia.Methods:Thirty Taihu healthy male piglets were selected.All pigle ts were induced to cardiac arrest and then were performed cardiopulmonary resusc itation.Following the recovery of spontaneous circulation,thirty piglets were r andomly divided into three groups:control group,Nal-1group and Nal-2group(10pi glets in each group).Normal saline,naloxone0.01mg/Kg and naloxone0.04mg/Kg wer e administrated intravenously in each group respectively.Those who survived the i nitial resuscitation were cared intensively for2hours(observation period)and w ere given further observation for24hours.The value of cTnI、TNFαandβ-EP was me asured respectively.Results:The cTnI reduced in both Nal-1group and Nal-2group w hile it increased in control group during the observation period(P0.01).There were no significant difference in the cTnI among three group at the24th hour(P 0.05).The TNFαin all three groups was lower than the normal value during the o bservation period,whereas it increased at the24th hour.NO significant differenc e in the TNFαwas found among three groups.Theβ-EP in all three groups increas ed during the observation period and decreased during the following24hours.Theβ -EP was significant higher in both Nal-1group and Nal-2group compared with contr ol group(P0.05).We found no significant difference in the value of cTnI、TNF α andβ-EP between Nal-1group and Nal-2group and no significant difference in the s urvival rate among all three groups,either.Conclusion:Naloxone may have cardiop rotective effects in piglets with hypoxia-induced cardiac arrest during the card iopulmonary resuscitation." @default.
- W2364264294 created "2016-06-24" @default.
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- W2364264294 date "2005-01-01" @default.
- W2364264294 modified "2023-09-28" @default.
- W2364264294 title "Cardioprotective effects of naloxone on piglets with hypoxia-induced cardiac ar rest" @default.
- W2364264294 hasPublicationYear "2005" @default.
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