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- W2364264807 abstract "Aim To investigate whether leptin can affect the injury induced by 5-fluorouracil (5-FU) on human colon cancer cell line HT-29 and examine the mechanisms involved. Methods HT-29 cells were cultured in vitro and 5-FU was given with or without different doses of leptin. The 50% cell inhibitory concentrations (IC_ 50 ) after treatment with 5-Fu were determined by MTT assay. The cell cycle and apoptosis were analyzed using flow cytometry and TUNEL. caspase-9 and caspase-3 were evaluated by RT-PCR. Results Leptin enhanced HT-29 cell proliferation. In addition, leptin counteracted 5-FU-induced cell cycle arrest and apoptosis. RT-PCR analysis demonstrated that the expression levels of caspase-9 and caspase-3 were reduced dose-dependently after leptin exposure. Conclusions Leptin exerted antiapoptotic effects on HT-29 cells and protective effects aganist 5-FU via down-regulation of two key genes of the death cascade, caspase-9 and caspase-3." @default.
- W2364264807 created "2016-06-24" @default.
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- W2364264807 date "2006-01-01" @default.
- W2364264807 modified "2023-09-24" @default.
- W2364264807 title "Protective effect of leptin on human HT-29 cell injury induced by 5-fluorouracil" @default.
- W2364264807 hasPublicationYear "2006" @default.
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