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- W2364267774 abstract "Objective: To investigate the effect of rosuvastatin on carotid atherosclerosis in elderly patients with diabetes mellitus(DM).Methods: Totally 92 DM patients with glycemic control and 52 elderly subjects with normal glucose tolerance(NGT) were compared.DM patients with 10 and 20mg·d-1 rosuvastatin for 12 months in addition to usual hypoglycemia medications,or with usual hypoglycemia medications alone(control group).The carotid intima-media thickness(IMT),carotid plaque,endothelium-dependent dilation(EDD),serum levels of lipid,and high-sensitive C reaction protein(HsCRP) were measured and analyzed.Results: Carotid IMT and atherosclerotic plaque were higher in DM group than in NGT group.Compared with pre-treatment,IMT did not change in 10mg·d-1 group and significantly decreased in 20mg·d-1 group after treatment.Plaque area significantly decreased in 10mg·d-1 group and decreased further in 20mg·d-1 group after treatment(P0.05).There was no significant difference in the two carotid parameters between pre-treatment and post-treatment.Furthermore,the change in IMT was correlated with the change in HsCRP or EDD.Conclusion: Rosuvastatin can retard or decrease carotid atherosclerosis in elderly DM patients." @default.
- W2364267774 created "2016-06-24" @default.
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- W2364267774 date "2011-01-01" @default.
- W2364267774 modified "2023-09-26" @default.
- W2364267774 title "Effect of rosuvastatin on carotid atherosclerosis in elderly patients with diabetes pellitus" @default.
- W2364267774 hasPublicationYear "2011" @default.
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