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- W2364270014 abstract "Objective To compare the efficacy and toxicity of CTOP(with THP)and CHOP(with ADM) in the treatment of peripheral T-cell lymphoma(PTCL).Methods The clinical characteristics of PTCL were reviewed,and the rate of response,toxicity and long-term survival were analysed retrospectively.Results Twenty-five of 29 patients with PTCL could be evaluated,of them,14 were treated with CTOP and 11 with CHOP regimen with a median follow up of 21.25 months.The clinical characteristics of the two groups were similar.The response rates for CTOP and CHOP were 78.6% and 72.7%,respectively(P0.05),and the complete remission rates were 57.1% and 54.5%,respectively(P0.05).The 3-year overall survival rates were 57.7% and 46.3%,and 5-year overall survival rates were 32.1% and 22.1%,respectively(P=0.012).169 courses were administered in 25 patients.The major toxicity was myelosuppression,with no significant difference between the groups(P0.05).The incidences of cardiotoxicity,alopecia and vomiting were higher in the CHOP group than in CTOP group(P0.05)).Conclusion CTOP(with THP) regimen may be more effective in treating PTCL with lower toxicity and better long-term survival.Further clinical trial is warranted to explore the efficacy in the elderly." @default.
- W2364270014 created "2016-06-24" @default.
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- W2364270014 date "2011-01-01" @default.
- W2364270014 modified "2023-09-25" @default.
- W2364270014 title "Long-term results of CTOP versus CHOP regimens on peripheral T-cell lymphoma" @default.
- W2364270014 hasPublicationYear "2011" @default.
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