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- W2364271709 abstract "Objective To study the correlation between serum levels of NO(nitric oxide),iNOS(nitric oxide synthase)and the degree of liver cell injury in patients with chronic liver deseases.Methods Serum levels of NO,iNOS were assayed with nitrate reductase enzymatic and spectrophotometric method and other index of liver function including alanine aminotransferase(ALT),alkaline phosphatase(ALP) activeness,total bilirubin(STB),direct bilirubin(SDB),albumin(ALB),total bile acid(TBA) levels in 168 patients with various chronic liver diseases and 60 controls were assayed with automatic biochemical analyzer.Results The serum levels of NO,iNOS were in the descending order of chronic severe hepatitis B group moderate chronic hepatitis B group liver cirrhosis from chronic hepatitis B group primary liver cancer mild chronic hepatitis B group normal control group.The serum levels of NO,iNOS were positive correlated with ALT,ALP(P 0.05) in mild chronic hepatitis B group.NO,iNOS levels in moderate chronic hepatitis B group were positively correlated with and STB,SDB,ALP(P0.05),and significantly correlated with ALT(P0.01);Chronic severe hepatitis B group's of NO,iNOS levels were positively correlated with STB,SDB,ALP,ALT(P0.01),and negatively correlated with ALB(P0.05);NO,iNOS levels in liver cirrhosis patients of chronic hepatitis B group and primary liver cancer patients were significantly positively correlated with STB,SDB,ALP(P0.01),and positively correlated with TBA,ALT0.05),and significantly negatively correlated with ALB(P0.01).Conclusion NO,iNOS levels varied in development process of liver damage from mild to severe and cirrhosis and they were correlated with the liver function,thus they can be used as a indicator for grading of livercell injury." @default.
- W2364271709 created "2016-06-24" @default.
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- W2364271709 date "2011-01-01" @default.
- W2364271709 modified "2023-09-23" @default.
- W2364271709 title "Correlation between serum levels of NO,iNOS and the degree of liver cell injury in chronic liver disease patients" @default.
- W2364271709 hasPublicationYear "2011" @default.
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