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- W2364271718 abstract "Objective To analyze the correlation between the findings by MRI in brain of children with Wilson disease and clinical manifestations before and after treatment.Methods The data of 50 patients with Wilson disease at first diagnosis were retrospectively analyzed.Among the 50 patients,20 patients were followed-up and examined by MRI,and 15 patients were retrospectively analyzed after treatment with penicillamine,then the correlation between the findings by MRI and clinical manifestations were analyzed.Results The patients were divided into 3 groups according to initial findings by MRI.Group I(n=23)showed normal findings by MRI;group II(n=15)was characterized by T1-weighted images with increased signal intensity in the globus pallidus followed by putamen,midbrain and caudate nucleus;Group III(n=12)showed T2-weighted images with increased signal intensity in the putamen followed by caudate nucleus,globus pallidus,thalamus,midbrain and pons.There were significant differences in mean age,manifestations of nervous system and Child-Pugh liver function classification among the 3 groups(P0.01).after clearing copper therapy,the changes showed by MRI at follow-up were closely correlated with clinical efficacy(P0.01).Conclusion The manifestations in brain showed by MRI in children with Wilson disease is closely related with therapeutic effect,so did that after treatment,as a result,MRI inspection plays an important role in evaluating the therapeutic effect for patients with Wilson disease." @default.
- W2364271718 created "2016-06-24" @default.
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- W2364271718 date "2007-01-01" @default.
- W2364271718 modified "2023-09-28" @default.
- W2364271718 title "Correlation between the findings by MRI in brain of children with Wilson disease and clinical manifestations" @default.
- W2364271718 hasPublicationYear "2007" @default.
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