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- W2364273496 abstract "Objective To compare the immunogenicity and safety of inactivated and live attenuated hepatitis A vaccines in Chinese young adults.Methods Healthy undergraduate students aged 16 to 25 years with anti-HAV negative were randomly divided into three groups.Group A and B were administrated with one-dose inactivated and live attenuated hepatitis A vaccines,respectively;Group C was immunized with two doses of inactivated vaccine at months 0 and 6.Blood samples were collected at months 1,1.5(from group A and B) or 7(from group C),and 12(from all groups) to detect the levels of anti-HAV.Vaccine safety was observed during the first 30 minutes at the injection-site and systemic side-effects were recorded for three consecutive days after vaccination.Results The anti-HAV seroconversion rates in groups A,B and C were 88.4%,82.0% and 100.0%,respectively;and GMC were 154.20 IU/L(95%CI:109.44-217.27 IU/L),89.99 IU/L(95%CI:59.60-135.89 IU/L) and 1 637.88 IU/L(95%CI:1 326.42-2 022.47 IU/L),respectively.Both inactivated and live attenuated vaccines at different regimens were well tolerated in young adults.The total incidence of adverse reactions was 2.9%.All side effects were mild and there were no significant differences among these three groups.Conclusions Both inactivated and live attenuated hepatitis A vaccines are highly immunogenic with safety profiles in young adults in China." @default.
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- W2364273496 date "2012-01-01" @default.
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- W2364273496 title "Immunogenicity and safety of inactivated and live attenuated hepatitis A vaccines in Chinese young adults" @default.
- W2364273496 hasPublicationYear "2012" @default.
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