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- W2364273852 abstract "Objective:To prepare the cyclosporin A(CsA) polylactic acid microspheres using solvent evaporation method from an oil-in-water system.Methods:Orthogonal experiment was used to optimize the method of CsA polylactic acid microspheres preparation.The microspheres were characterized for drug loading and entrapment efficiency by high-performance liquid chromatography(HPLC),average size by particle size analyser and surface morphology by scanning electron microscopy(SEM).In vitro the release kinetics were studied using a modified dialysis method.Results:SEM studies showed discrete and spherical particles with smooth surfaces.The average particle size was 18.234 μm,with more than 80% of the microspheres falling in the range of 9.525-32.400 μm.The drug loadings ranging was(34.51±0.63)% with a high encapsulation efficiency(86.12±0.77)% determined by HPLC.In vitro release study revealed a profile of sustained release of CsA from CsA-PLA-MS.The accumulated release percentage of CsA microspheres were 40.8% in 30 d.CsA release profiles show CsA release could be divided by two different phases,fast release within the first few days and the subsequent sustained release.Conclusion:CsA polylactic acid microspheres have been successfully prepared and sustained release of CsA from microspheres have been achieved." @default.
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- W2364273852 date "2007-01-01" @default.
- W2364273852 modified "2023-09-23" @default.
- W2364273852 title "Preparation of cyclosporin A polylactic acid microsphere for topical application" @default.
- W2364273852 hasPublicationYear "2007" @default.
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