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- W2364274928 abstract "Objective:To elucidate the role of loss of heterozygosity(LOH)of DCC in carcinogenesis and development of gastric carcinoma and its relationship wifh clinicopathological factors in primary gastric carcinoma.Methods:Forty-nine cases of primary gastric carcinoma were studiel by polymerase chain reactionsingle strand conformation polymorphism(PCR-SSCP)and silver staining to detect the loss of heterozygosity(LOH)of DCC.Results:The incidence of LOH in D18S484was ob-served in26.6%(12/45);in D18S487,23.9%(11/46);in DCC,36.7%(18/49).The rate of DCC LOH was36.8%(7/19)in fhe intestinal-type.of gastric camcer,24.0%(6/25)in fhe diffuse-type and and100%(5/5)in fhe mixed-type(P0.05).The prevalence of DCC LOH was significantly higher in cases wifhpatients with lymph node metastasis(52%)than fhose in those without lymph node metastasis(20.8%)(P0.05),and X more significantly higher in cases wifh distant metatasis(P0.05).There was a trend towards a higher in incidence of DCC LOH in StogesⅢδⅣcases those in SragosⅠandⅡ(24%)(P=0.059).Conclusions:The DCC LOH miyht enhance fhe progression andoccurrence of metastasis in gastric carcinoma." @default.
- W2364274928 created "2016-06-24" @default.
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- W2364274928 date "2003-01-01" @default.
- W2364274928 modified "2023-09-27" @default.
- W2364274928 title "Study on loss of heterozygosity of DCC in primary gastric carcinoma." @default.
- W2364274928 hasPublicationYear "2003" @default.
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