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- W2364276435 abstract "Objective To establish the model of ischemic white matter damage in neonatal rat and study the changes of apoptosis in subventricular zone of the models. Methods Ninety-six 3-day-old neonatal rats were selected and randomly divided into experimental group and control group. The model with ischemic brain white matter damage was established by bilateral carotid artery occlusion (BCAO). Their body weight and brain weight were measured at 24 h、48 h、72 h、7 d、14 d after ischemia. Their neuropathologic changes and apoptosis in subventricular zone (SVZ) were observed in each group. Results Body weight and brain weight gaining in experimental group was significantly slower in experimental group, P0.01. The degeneration and necrosis of neurons were observed by HE staining in experimental group, and the size of lateral ventricle in the experimental group was larger than those of control group, P0.01. The number of myelin sheath in corpus striatum in experimental group was significantly less than that of control group, P0.05. The corpus callosum in experimental group was thinner, P0.01. The number of apoptotic cells in SVZ increased at 48th hour and reached peak at 72nd hour after the BCAO operation in each experimental groups. There was a significant difference between two groups, P0.01. Conclusions The model with ischemic brain white matter damage is successfully established by applying method of BCAO. Significant apoptosis is observed in the early period of brain damage." @default.
- W2364276435 created "2016-06-24" @default.
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- W2364276435 date "2007-01-01" @default.
- W2364276435 modified "2023-09-26" @default.
- W2364276435 title "Laboratory study on model with ischemic white matter damage in 3-day-old neonatal rats" @default.
- W2364276435 hasPublicationYear "2007" @default.
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