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- W2364276783 abstract "Objective: To investigate the effects of Keluoxin capsule on hypoxia-induced angiogenesis in retina. Method: In vitro,cultured ARPE-19 was pretread with 5,10,20 mg·L-1Keluoxin for 24 hours,before 150 μmol·L-1CoCl2treatment for 24 hours,ELISA and Western blotting were used to detected the level of vascular endothelia growth factor(VEGF) and hypoxia inducible factor 1 alpha(HIF1-α),expressions of VEGF and HIF1-α mRNA were measured by real-time PCR. In vivo,sixty C57BL/6J mice were randomly divided into six groups as follows: control group,retinopathy(OIR) model group,calcium dobesilate group and Keluoxin groups. In control group,mice were raised in regular air environments. The fifty mice were fed under the environment with 75% ± 2% oxygen for five days and then returned to normal air to establish OIR model. The 0. 5 g·kg-1calcium dobesilate was administered by gavage feeding once daily in calcium dobesilate group,and 0. 5,1. 0,2. 0 g·kg-1 Keluoxin were gavaged as low,middle and high dosage Keluoxin groups respectively. Five days later,the mice were sacrificed using excessive anesthesia method and the retinal sections were prepared for the calculation of the number of endothelial cell nuclei broken retinal inner membrane after hemotoxylin and eosin staining. The morphologic changes of retinal vessels were observed after ADPase staining. Result: The VEGF secretion,mRNA expression of VEGF and HIF1-α of CoCl2group were significantly higher than control group(P 0. 001),and those were decreased by 10,20 mg·L-1Keluoxin remarkably(P 0. 01 and P 0. 05). In vivo,there was a obvious reduction in expansion,deformation and A value of vascular in Keluoxin groups compared with OIR model group,and the number of cell nuclei broken the inner limiting membrane had decreased in Keluoxin groups(P 0. 01) significantly. Conclusion: Keluoxin capsule can inhibit hypoxia-induced VEGF secretion and neovascularization in retina." @default.
- W2364276783 created "2016-06-24" @default.
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- W2364276783 date "2014-01-01" @default.
- W2364276783 modified "2023-09-25" @default.
- W2364276783 title "Inhibitory Effects of Keluoxin Capsule on Hypoxia-induced Angiogenesis in Retina" @default.
- W2364276783 hasPublicationYear "2014" @default.
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