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- W2364277782 abstract "Objective:To investigate whether simvastatin has different influences on differentiation of rat smooth muscle progenitor cells(SPCs) and endothelial progenitor cells (EPCs) and to identify the compounds that differentially inhibit SPC and EPC differentiation for substantial clinical usefulness.Methods:Total mononuclear cells (MNCs) were isolated from marrow of rats by ficoll density gradient centrifugation,and then the cells were plated on fibronectin-coated culture dishes.SPCs outgrew from the culture of MNCs in SPC medium (the presence of platelet-derived growth factor-BB and basic fibroblast growth factor),whereas EPCs were obtained in EPC medium (the presence of vascular endothelial growth factor).SPCs were identified as adherent cells positive for α-SMA by indirect immuno-fluorescent staining.EPCs were characterized as adherent cells double positive for DiLDL-uptake and lectin binding by direct fluorescent staining.MNCs in SPC medium and EPC medium were treated with simvastatin (0.01～10 μmol/L) or vehicle control for 8 d,SPCs and EPCs were assayed with manual counting.Results:Simvastatin potently inhibited MNC differentiation to SPC.At a concentration as low as 0.01 μmol/L for 8 d,simvastatin significantly reduced SPC compared with that in control,(0.01μmol/L simvastatin versus control:79±5 vs 85±4,P0.05).Different from SPC,simvastatin dose-dependently increased the number of EPC,with maximum at 1μmol/L,the number of differentiating EPCs significantly increased (1μmol/L simvastatin versus control:87±5 vs 39±4,P0.01).Conclusion:Simvastatin of equal dosage displays differential effects on MMC differentiation characterized by inhibiting SPC differentiation but promoting EPC differentiation from the bone marrow MNC." @default.
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- W2364277782 date "2010-01-01" @default.
- W2364277782 modified "2023-09-25" @default.
- W2364277782 title "Effects of simvastatin on differentiation of smooth muscle progenitor cells and endothelial progenitor cells in rats" @default.
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