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- W2364281377 abstract "Objective: To observe the circadian rhythm of ventilation function in nocturnal asthma and the relationship of inflammation mediator leukotriene(LT) and nocturnal asthma.Methods: Three groups were studied: 20 patients with nocturnal asthma;22 asthmatic patients without nocturnal attacks;20 control subjects.PEF,FEV1% and mouth closed pressure(P0.1) were measured at 04:00,08:00,16:00 22:00.LTE4 was measured by EIA.Results: In nocturnal asthmatic group ventilation function was highest at 16:00 and lowest at 04:00.A significant correlation was observed between the increase of P0.1 and the decreased PEF,FEV1% at night in nocturnal asthma(P0.01).At 21:01~ 9:00,LTE4 was significantly higher in nocturnal asthma(324.22±222.51) than in non-nocturnal asthma(194.95±76.52) and health(201.11±68.57).And in nocturnal asthma LTE4 at 21:01~ 9:00 was significantly higher than that of 9:01~15:00(P0.01).Conclusion: In nocturnal asthma,ventilation function takes on circadian rhythm.The change of LT may contribute to the nocturnal worsening of asthma." @default.
- W2364281377 created "2016-06-24" @default.
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- W2364281377 date "2006-01-01" @default.
- W2364281377 modified "2023-09-26" @default.
- W2364281377 title "Study of circadian rhythm of respiratory function and leukotriene in nocturnal asthma" @default.
- W2364281377 hasPublicationYear "2006" @default.
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