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- W2364286824 abstract "【Objective】 To study the mechanisms of homocysteine (Hcy) inducing extracellular superoxide dismutase mRNA and protein expression and oxidative stress in hypertensive disorders in pregnancy (PIH).【Methods】 The Hcy level of 107 pregnancy patients with hypertensive disorders and 40 health adults was measured by fluorescence polarization.PIH patients were divided into four groups by Hcy level: PIH Hcy normal group,PIH Hcy light range group,PIH Hcy midrange group and PIH Hcy serious group.The level of GSH-px,SOD,MDA and ox-LDL was detected by ELISA.EC-SOD mRNA and protein expression in blood plasma lymphomonocytes was measured by real time RT-PCR and Western blot respectively.【Results】 With the increase of Hcy level,the levels of MDA and ox-LDL in PIH patients were increased,the levels of GSH-px and SOD were decreased,the levels of EC-SOD mRNA and protein were lowered (P 0.05) in a dose-dependent manner.【Conclusion】 Homocysteine may play a crucial role in PIH by decreasing the expression of EC-SOD mRNA and protein and inducing oxidative stress." @default.
- W2364286824 created "2016-06-24" @default.
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- W2364286824 date "2010-01-01" @default.
- W2364286824 modified "2023-09-24" @default.
- W2364286824 title "Mechanisms of homocysteine inducing extracellular superoxide dismutase mRNA and protein expression in hypertensive disorders in pregnancy" @default.
- W2364286824 hasPublicationYear "2010" @default.
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