Matches in SemOpenAlex for { <https://semopenalex.org/work/W2364286844> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2364286844 abstract "Objective To investigate whether there is an association between plasma nitric oxide(NO)concentrations or neuronal nitric oxide synthase(nNOS)gene C276T polymorphism and antidepressant effect in depressed patients.Methods Plasma NO concentrations were measured in depressed patients before and after 8-weeks SSRIs antidepressant treatment and normal controls by spectrophotometer.The 17-item Hamilton Depression Rating Scale(HAMD)was used to evaluate clinical depression symptom.The HAMD reduction ratio was used to evaluate the antidepressant effect.Genotyping was performed using PCR-RFLP techniques both in patients and normal controls.Results The plasma NO concentrations in acute episode untreated depressed patients(76.8±31.6)μmol/L were significantly higher than that in the patients after 8-weeks antidepressant treatment [(66.9±25.7)μmol/L,P=0.044]and normal controls[(64.2±33.3)μmol/L,P=0.02].There was no significant difference between the plasma NO concentrations in treated patients and normal controls(P=0.588).The plasma NO concentrations in untreated patients were significantly positively associated with baseline HAMD scores(24.3±4.3)(r=0.311,P=0.009).Genotypes of nNOS were not associated with HAMD scores(P0.05).Conclusion These data provide a possibility that plasma NO concentrations are likely to be indicator for severity of the clinical symptoms in depressend patients.The nNOS gene C276T polymorphism are unlikely to play important roles on antidepressant effect." @default.
- W2364286844 created "2016-06-24" @default.
- W2364286844 creator A5054186170 @default.
- W2364286844 date "2010-01-01" @default.
- W2364286844 modified "2023-09-28" @default.
- W2364286844 title "Study of the association between neuronal nitric oxide synthase gene polymorphism and antidepressant effect in depressed patients" @default.
- W2364286844 hasPublicationYear "2010" @default.
- W2364286844 type Work @default.
- W2364286844 sameAs 2364286844 @default.
- W2364286844 citedByCount "0" @default.
- W2364286844 crossrefType "journal-article" @default.
- W2364286844 hasAuthorship W2364286844A5054186170 @default.
- W2364286844 hasConcept C104317684 @default.
- W2364286844 hasConcept C126322002 @default.
- W2364286844 hasConcept C134018914 @default.
- W2364286844 hasConcept C135763542 @default.
- W2364286844 hasConcept C138496976 @default.
- W2364286844 hasConcept C139719470 @default.
- W2364286844 hasConcept C149737253 @default.
- W2364286844 hasConcept C15744967 @default.
- W2364286844 hasConcept C162324750 @default.
- W2364286844 hasConcept C185592680 @default.
- W2364286844 hasConcept C2776466505 @default.
- W2364286844 hasConcept C2776867660 @default.
- W2364286844 hasConcept C2777198177 @default.
- W2364286844 hasConcept C2777622882 @default.
- W2364286844 hasConcept C2779144063 @default.
- W2364286844 hasConcept C2779177272 @default.
- W2364286844 hasConcept C2780051608 @default.
- W2364286844 hasConcept C2781161787 @default.
- W2364286844 hasConcept C3018023364 @default.
- W2364286844 hasConcept C519581460 @default.
- W2364286844 hasConcept C55493867 @default.
- W2364286844 hasConcept C71924100 @default.
- W2364286844 hasConcept C83849319 @default.
- W2364286844 hasConcept C90924648 @default.
- W2364286844 hasConceptScore W2364286844C104317684 @default.
- W2364286844 hasConceptScore W2364286844C126322002 @default.
- W2364286844 hasConceptScore W2364286844C134018914 @default.
- W2364286844 hasConceptScore W2364286844C135763542 @default.
- W2364286844 hasConceptScore W2364286844C138496976 @default.
- W2364286844 hasConceptScore W2364286844C139719470 @default.
- W2364286844 hasConceptScore W2364286844C149737253 @default.
- W2364286844 hasConceptScore W2364286844C15744967 @default.
- W2364286844 hasConceptScore W2364286844C162324750 @default.
- W2364286844 hasConceptScore W2364286844C185592680 @default.
- W2364286844 hasConceptScore W2364286844C2776466505 @default.
- W2364286844 hasConceptScore W2364286844C2776867660 @default.
- W2364286844 hasConceptScore W2364286844C2777198177 @default.
- W2364286844 hasConceptScore W2364286844C2777622882 @default.
- W2364286844 hasConceptScore W2364286844C2779144063 @default.
- W2364286844 hasConceptScore W2364286844C2779177272 @default.
- W2364286844 hasConceptScore W2364286844C2780051608 @default.
- W2364286844 hasConceptScore W2364286844C2781161787 @default.
- W2364286844 hasConceptScore W2364286844C3018023364 @default.
- W2364286844 hasConceptScore W2364286844C519581460 @default.
- W2364286844 hasConceptScore W2364286844C55493867 @default.
- W2364286844 hasConceptScore W2364286844C71924100 @default.
- W2364286844 hasConceptScore W2364286844C83849319 @default.
- W2364286844 hasConceptScore W2364286844C90924648 @default.
- W2364286844 hasLocation W23642868441 @default.
- W2364286844 hasOpenAccess W2364286844 @default.
- W2364286844 hasPrimaryLocation W23642868441 @default.
- W2364286844 hasRelatedWork W134314922 @default.
- W2364286844 hasRelatedWork W1766279608 @default.
- W2364286844 hasRelatedWork W1979081313 @default.
- W2364286844 hasRelatedWork W2000169475 @default.
- W2364286844 hasRelatedWork W2012461838 @default.
- W2364286844 hasRelatedWork W2041814518 @default.
- W2364286844 hasRelatedWork W2074258143 @default.
- W2364286844 hasRelatedWork W2075931039 @default.
- W2364286844 hasRelatedWork W2088770573 @default.
- W2364286844 hasRelatedWork W2102482056 @default.
- W2364286844 hasRelatedWork W2123311593 @default.
- W2364286844 hasRelatedWork W2167565363 @default.
- W2364286844 hasRelatedWork W2412743680 @default.
- W2364286844 hasRelatedWork W2740684052 @default.
- W2364286844 hasRelatedWork W2752861384 @default.
- W2364286844 hasRelatedWork W2787370175 @default.
- W2364286844 hasRelatedWork W2907994424 @default.
- W2364286844 hasRelatedWork W2980174964 @default.
- W2364286844 hasRelatedWork W3002221608 @default.
- W2364286844 hasRelatedWork W3158881645 @default.
- W2364286844 isParatext "false" @default.
- W2364286844 isRetracted "false" @default.
- W2364286844 magId "2364286844" @default.
- W2364286844 workType "article" @default.