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- W2364288813 abstract "ObjectiveTo investigate the effect of intravenous administration of human umbilical cord blood cells(HUCBCs) on active avoidance response (AAR) ratio on vascular dementia rats and investigate the effect of these cells on apoptosis of hippocampi in vascular dementia rats.MethodsThe rats were randomly divided into a model group, a treatment group and a control group. The three groups were observed at 2, 4 and 8 weeks, respectively. Serum samples of rats were taken at 2, 4 and 8 weeks after operation. A widespread nuclear terminal deoxynucleotidyl-transferase-mediated dUTP nick end labeling (TUNEL) was used to identify apoptotic cells in hippocampi of the rats.ResultsBehavioral tests showed the AAR ratio in the treatment group 2nd week (68.9±7.0),4th week(69.6±8.2),8th week (70.8±7.4)was significant higher than that in the model group. TUNEL positive cells in hippocampus in the control group were obviously more than those in the treatment group.ConclusionBehavioral test showed that HUCBCs therapy could improve cognition function of VaD rats,and intravenous administration HUCBCs could reduce apoptosis cells in hippocampus." @default.
- W2364288813 created "2016-06-24" @default.
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- W2364288813 date "2006-01-01" @default.
- W2364288813 modified "2023-09-24" @default.
- W2364288813 title "The effect of intravenous administration of human umbilical cord blood cells on behavior and apoptosis in hippocampi in vascular dementia rats" @default.
- W2364288813 hasPublicationYear "2006" @default.
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