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- W2364293623 abstract "Objective To investigate the serum concentration of N e carboxymethyl lysine(CML),an advanced glycosylation end product (AGE),in patients with coronary heart disease (CHD).Methods Competitive ELISA using the antibody specific for KLH AGE was used to examine serum levels of CML in 33 cases of CHD,38 health subjects and 14 cases of hypertension.Results CML was detectable (0.1 mg/L) in 100% of CHD patients as compared with 7.9% in age matched normal subjects (P0.001).Plasma levels of CML were elevated in the hypertensive CHD patients[(0.92±0.61) mg/L] as compared with hypertension [(0.23±0.16) mg/L]or normotensive CHD [(0.44±0.47) mg/L] patients (P0.01 and P0.05).There was no difference in serum concentration of CML between diabetic and non diabetic CHD patients.Conclusion The presence of CML in serum suggests a potential link between the pathogenesis of atherosclerosis and the accumulation of AGE in CHD patients.CML may be used as a biomarker of advanced glycosylative reaction in CHD patients." @default.
- W2364293623 created "2016-06-24" @default.
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- W2364293623 date "2000-01-01" @default.
- W2364293623 modified "2023-09-25" @default.
- W2364293623 title "Changes in serum concentration of the advanced glycosylation end product N epsilon (carboxymethyl) lysine in patients with coronary heart diseases" @default.
- W2364293623 hasPublicationYear "2000" @default.
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