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- W2364295689 abstract "Objective To study the influence of β- adrenoreceptor pathway on ventricular remodeling of rats with heart failure and the regulative effect of Tongxinluo on it. Methods Rat model with ventricular remodeling was made by the way of myocardial infarction. Six weeks later, the parameter of hemodynamics was determined,β - adren-ergic receptor density(Bmax )and the content of cAMP were measured, and the changes of the ultrastructure were observed as well.Results In comparation with false operation group,the blood pressure,(β-adrenergic receptor density and content of c AMP was reduced in ventricular remodeling group and Tongxinluo group, but LVEDP was raised. SBP, LVSP, + dp/dtmax, - dp/dtmax ,(3 - adrenergic receptor density and content of cAMP were increased more significanthy in Tongxinluo group than in ventricular remodeling group ( P 0.05) . The fibroblast proliferation, collagen sludge and collagen fiber deposit were found by electron microscopy on intersexuality of rats in ventricular remodeling. These pathologic changes were more slight in Tongxinluo group than in ventricular remodeling group. Conclusion Tongxinluo can improve the cardiac function of rats with ventricular remodeling, increase myocardium Bmax the contents of c AMP, and relieve the myocardium pathologic lesion caused by remodeling in the rats. Tongxinluo could partially depress the ventricular remodeling of rats with heart failure after myocardial infarction." @default.
- W2364295689 created "2016-06-24" @default.
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- W2364295689 date "2002-01-01" @default.
- W2364295689 modified "2023-09-25" @default.
- W2364295689 title "Experimental study on depressing ventricular remodeling of rate by regulation of β-adrenoreceptor pathway with Tongxinluo" @default.
- W2364295689 hasPublicationYear "2002" @default.
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