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- W2364295934 abstract "Aim:To study the expression and clinical significance of stromal cell derived factor 1(SDF-1) and vascular endothelial growth factor(VEGF) in the bone marrow mononuclear cells of patients with acute leukemia(AL).Methods:The expressions of SDF-1 and VEGF in the bone marrow mononuclear cells from untreated AL group(65 cases),AL complete remission(AL-CR)group(20 cases),relapsing,refractory AL(RRAL) group(24 cases),and normal control group(15 cases) were detected by immunohistochemical SP assay.Results:The positive expression rates of SDF-1 and VEGF in untreated AL group [67.7%(44/65) and 64.6%(42/65)] were significantly higher than RRAL group[70.8%(17/24)and 66.6%(16/24)],AL-CR group [15.0%(3/20)and 20.0%(4/20)],and normal contral group[6.6%(1/15)and 13.3%(2/15)](χ2=33.159,23.382,P0.001).The expressions of SDF-1 and VEGF were related with the number of WBC in peripheral blood(χ2=11.413 and 15.363,P0.001) and leukemic infiltration(χ2=10.100 and 13.333,P0.001).Conclusion:The overexpression of SDF-1 and VEGF in AL may play an important role in the pathogenesis,progression,infiltration,relapse and metastasis.It is contributed to judge prognosis and curative effect of AL by testing the change of expression of SDF-1 and VEGF dynamically." @default.
- W2364295934 created "2016-06-24" @default.
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- W2364295934 date "2010-01-01" @default.
- W2364295934 modified "2023-09-26" @default.
- W2364295934 title "Expression of SDF-1 and VEGF in the bone marrow mononuclear cells of patients with acute leukemia" @default.
- W2364295934 hasPublicationYear "2010" @default.
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