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- W2364301060 abstract "Objective:To evaluate the effects of captopril take n be fore operation on blood pressure in patients with infrarenal aortic aneurysm dur ing operation.Methods:Twenty-five patients with infrarenal aorti c aneurysm were randomly divided into two groups:control group(group A,n=10)and c aptopril group(group B,n=15).In Group B,captopril(15mg per patient)was orally ad ministrated 30 minutes before operation.Radial arterial pressure(MAP)and centra l venous pressure(CVP)were recorded before aortic clamping,5minutes and 10 minute s after clamping,and 10 minutes after declamping,respectively.The angiotensin-Ⅱ (AT-Ⅱ)and endothelins-L(ET-Ⅰ)content in plasma were assayed before clamping,af t er clamping and after declamping.Results:In group A,MAP increas ed significantly after clamping(P0 01 or P0 05)and decreased significantly a fter declamping(P0 05).However,there were no remarkable changes durin g operat ion in group B.Compared with group A,MAP 5 minutes after clamping in group B was significantly lower (P0 05)and it obviously increased 10 minutes after decla mping(P0 05).CVP in group A increased significantly after clamping and no rem arkable changes of CVP were observed in group B.In group A,AT-Ⅱand ET-Ⅰalso in c reased in group B after clamping and declamping,While they were lower than that in group A.Conclusion:Taking captopril before operation can alle viate hypertension response after aortic clamping and hypotension after declampi ng,which might be related to its decreasing the release of AT-Ⅱ and ET-Ⅰ" @default.
- W2364301060 created "2016-06-24" @default.
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- W2364301060 date "2004-01-01" @default.
- W2364301060 modified "2023-09-25" @default.
- W2364301060 title "Effects of captopril taken before operation on blood pressuse in patients during infrarenal aortic clamping and declamping" @default.
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