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- W2364302259 abstract "Objective To study the potential improvement of donor heart storage by adenosine preconditioning.Methods Rabbit hearts were isolated and mounted on a Langendorff apparatus,perfused with filtered modified Krebs-Henseleit buffer through left atria,instrumented left ventricular function monitor system and paced ventricularly at 180 beats/min.Isolated hearts were grouped into three groups and subjected to normal perfusion or to solution supplemented with adenosine 50 μmol/L for 10 min utes followed by adenosine-free K-H or ischemic preconditioning (5 minute ischemia and 10 minute perfusion).Hearts then were arrested with 4℃ modified St.Thomas solution,and stored for 4 hours at 4℃in this solution and reperfused with K-H buffer.Left ventricular function,myocardial CK-mb leakage and tissue levels of adenosine triphosphate were measured.Results Hearts preconditioned with adenosine or ischemia had better function expressed as recovery percentage(+dp/dt max(74.56±14.38),(68.38±10.47),respectively).If compared with control group(32.45±9.46),the differences were significant(P0.05).Conclusion This study suggests the transient preconditioning with adenosine have some beneficial effects on donor heart preservation." @default.
- W2364302259 created "2016-06-24" @default.
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- W2364302259 date "2003-01-01" @default.
- W2364302259 modified "2023-09-23" @default.
- W2364302259 title "Improvement of donor heart storage by adenosine preconditioning" @default.
- W2364302259 hasPublicationYear "2003" @default.
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