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- W2364303926 abstract "AIM:To explore the protective effect of pretreatment with pentamethylquercetin(PMQ) on anoxia/reoxygenation(A/R) injury and mitochondrial function in rat cardiomyocytes. METHODS:Primary neonatal SD rat cardiomyocytes were cultured and pretreated with PMQ in final dose of 10,30,100 μmol/L for 24 h,and then underwent A/R injury.After treatment,the activity of LDH was determined by auto-biochemistry analysator,cells viability was analyzed by MTT,cell apoptosis and mitochondrial membrane potential were detected by flow cytometry,opening of mitochondrial permeability transition pore(mPTP) was determined by Ca2+-induced swelling of isolated cardiac mitochondria. RESULTS:Pretreated with different dose of PMQ(10,30,100 μmo/L) for 24 h could reduce LDH activity,increase cell viability,decrease cell apoptosis(P0.05 or P0.01)in dose-dependent manner;Moreover,pretreated with 30,100 μmol/L PMQ for 24 h,mitochondrial membrane potential could be more stable(P0.05 or P0.01),and the opening of mPTP could be more lessened(P0.05 or P0.01). CONCLUSION:Pretreated with PMQ for 24 h could have Pharmacology delay protection,the mechanism involved in stabilizing mitochondrial membrane potential,inhibiting mPTP opening,and reducing cell apoptosis." @default.
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- W2364303926 date "2013-01-26" @default.
- W2364303926 modified "2023-09-24" @default.
- W2364303926 title "Effect of pretreatment with pentamethylquercetin on mitochondrial function in rat cardiomyocyte" @default.
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