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- W2364305710 abstract "· AIM: To study the subpopulations of cells infiltrating the allograft and the phenotypes in draining lymph node in the murine corneal allograft rejection. · METHODS: Using a mouse corneal graft model, eyes were evaluated by clinical observation and fluorescent immunohistochemistry at various times. The phenotype of the leukocytes in the submandibular lymph node (SM LN) and superfacial cervical lymph node (SC LN) were studied by three-color flow cytometric analysis (FACS) 3d after transplantation.· RESULTS: 6h after corneal transplantation, neutrophils, dendritic cells, macrophages were present and gradually infiltrated the graft. CD4+and CD8+Tcells appeared at 24h and reached peak at 2wk. All the allografts were rejected with in 12-21d after transplantation. 3d after the transplantation, there was an early reduction of CD4+Tcells in SM LN compared with the nontransplanted mice (P = 0.038), whereas no obvious changes of leukocyte in the SC LN.· CONCLUSION: After corneal allograft transplantation, there is an acute infiltration of myeloid and lymphoid cells in the graft, which is consistent with the early reduction of CD4+Tcells in SM LN.·" @default.
- W2364305710 created "2016-06-24" @default.
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- W2364305710 date "2005-01-01" @default.
- W2364305710 modified "2023-09-28" @default.
- W2364305710 title "Characterization of cells infiltrating the graft and leukocyte phenotypes in draining lymph node in murine corneal allograft rejection" @default.
- W2364305710 hasPublicationYear "2005" @default.
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